João Paulo Oliveira–Costa

Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade

Daniel A. Ruiz‐Torres, Jillian F. Wise, Brian Y. Zhao, João Paulo Oliveira–Costa et autres

The potent immunostimulatory effects of toll-like receptor 8 (TLR8) agonism in combination with PD-1 blockade have resulted in various preclinical investigations, yet the mechanism of action in humans remains unknown. To decipher the combinatory mode of action of TLR8 agonism and PD-1 …

us (code pays fourni par la source)

Dendritic cell effector mechanisms and tumor immune microenvironment infiltration define TLR8 modulation and PD-1 blockade

Daniel A. Ruiz‐Torres, Jillian F. Wise, Brian Y. Zhao, João Paulo Oliveira–Costa et autres

Abstract The potent immunostimulatory effects of toll-like receptor 8 (TLR8) agonism in combination with PD-1 blockade have resulted in various preclinical investigations, yet the mechanism of action in humans remains unknown. To decipher the combinatory mode of action of TLR8 agonism and …

us (code pays fourni par la source)

Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells

Samantha J Linder, Tiziano Bernasocchi, Bárbara Martínez-Pastor, Kelly D. Sullivan et autres

us, es, be, il (code pays fourni par la source)

Partial freezing of rat livers extends preservation time by 5-fold

Shannon N. Tessier, Reinier J. de Vries, Casie A. Pendexter, Stephanie E. J. Cronin et autres

The limited preservation duration of organs has contributed to the shortage of organs for transplantation. Recently, a tripling of the storage duration was achieved with supercooling, which relies on temperatures between -4 and -6 °C. However, to achieve deeper metabolic stasis, lower …

us, nl, Égypte (code pays fourni par la source)

Abstract 1132: Multiplexed immunofluorescence and multispectral imaging-based quantification of tumor and immune cell populations reveals spatial relationships in oral cavity squamous cell carcinoma

João Paulo Oliveira–Costa, Anuraag S. Parikh, Linda T. Neiman, Derin Sevenler et autres

Recent single cell expression profiling of head and neck squamous cell carcinoma (HNSCC) identified a partial epithelial-to-mesenchymal transition (p-EMT) subpopulation of cancer cells. We have previously demonstrated an association of p-EMT subpopulations with adverse clinical and pathologic features, in both TCGA expression …

us, il (code pays fourni par la source)

Abstract 1132: Multiplexed immunofluorescence and multispectral imaging-based quantification of tumor and immune cell populations reveals spatial relationships in oral cavity squamous cell carcinoma

João Paulo Oliveira–Costa, Anuraag S. Parikh, Linda T. Neiman, Derin Sevenler et autres

Abstract Recent single cell expression profiling of head and neck squamous cell carcinoma (HNSCC) identified a partial epithelial-to-mesenchymal transition (p-EMT) subpopulation of cancer cells. We have previously demonstrated an association of p-EMT subpopulations with adverse clinical and pathologic features, in both TCGA …

us, il (code pays fourni par la source)

Blood-based biomarkers for the diagnosis and monitoring of gliomas

Marcus Zachariah, João Paulo Oliveira–Costa, Bob S. Carter, Shannon L. Stott et autres

Monitoring patient response to treatment is challenging for most cancers, but it is particularly difficult in glioblastoma multiform, the most common and aggressive form of malignant brain tumor. These tumors exhibit a high degree of heterogeneity which may not be reflected in …

us (code pays fourni par la source)

Gene expression patterns through oral squamous cell carcinoma development: PD-L1 expression in primary tumor and circulating tumor cells

João Paulo Oliveira–Costa, Alex F. Carvalho, Giórgia Gobbi da Silveira, Peter Amaya et autres

// Joao Paulo Oliveira-Costa 1 , Alex Fiorini de Carvalho 2 , Giorgia Gobbi da Silveira 1 , Peter Amaya 3 , Yongqi Wu 3 , Kyoung-Joo Jenny Park 3 , Mabel Pinilla Gigliola 2 , Maryam Lustberg 4 , Marcilei Eliza …

br, us (code pays fourni par la source)

PD‐L1 Expression in Oral Squamous Cell Carcinoma and Circulating Tumor Cells: Prognostic Significance

João Paulo Oliveira–Costa, Giórgia Gobbi da Silveira, Fernando Augusto Soares, Jeffrey J. Chalmers et autres

Oral squamous cell carcinoma (OSCC) is the most common type of malignant tumor of the oral cavity and has been associated with bad prognosis. The aim of this study is to verify differences in expression between tumors of different T stages, looking …

br, us (code pays fourni par la source)

Breast Cancer Stem Cells

Giórgia Gobbi da Silveira, João Paulo Oliveira–Costa, Alfredo Ribeiro‐Silva

br (code pays fourni par la source)

BRCA1 and γH2AX as independent prognostic markers in oral squamous cell carcinoma

João Paulo Oliveira–Costa, Lucinei Roberto Oliveira, Juliana Silva Zanetti, Giórgia Gobbi da Silveira et autres

Oral squamous cell carcinomas (OSCC) are believed to originate from sequential mutations that can develop as a consequence of genetic instability acquired over time. BRCA1 are linked to DNA recombination and repair processes, being of importance for its role in regulation of …

br (code pays fourni par la source)

Identification of expression profiles associated to oral squamous cell carcinoma development by cDNA microarrays (1047.13)

João Paulo Oliveira–Costa, Mabel Gigliola, Dirce Maria Carraro, Fernando Augusto Soares et autres

Oral squamous cell carcinoma (OSCC) development still a poorly understood phenomenon, in terms of gene expression profiles which might be involved in alterations leading to high invasiveness and aggressive behavior. Also, it stills unclear how gene expression changes during OSCC development, in …

br (code pays fourni par la source)