Qibao Zheng

Rational Design of Lysosome-Targeted Iridium(III) Complex for HClO Imaging and Monitoring Drug-Induced Bidirectional HClO Dynamics

Han Diao, Chongjie Ye, Lishi Deng, Yuan Li et autres

Abstract A series of Ir(III) complexes targeting lysosomes and bearing an imino ortho phenylene HClO recognition unit was developed for selective HClO imaging. In these probes, electrophilic addition triggered by HClO at the recognition unit modulates emission from the Ir(III) coordination core, …

cn (code pays fourni par la source)

Spike-Aware Propagation Approximation for Conductance-Based LIF Equations

Yi Yu, Qibao Zheng, Wenlian Lu

Large-scale spiking neural network simulation requires numerical integration that preserves membrane dynamics and spike timing without making fine-resolution updates prohibitively expensive. This balance is difficult for conductance-based leaky integrate-and-fire (LIF) networks because synaptic decay, threshold crossings, resets, and refractory periods form a …

Digital Twin Brain simulation and manipulation of a functional brain network underlying mental illness

Yunman Xia, Songjun Peng, Juergen Dukart, Y. Xie et autres

Linking synaptic-level perturbations to distributed brain-network dynamics remains a central challenge for understanding and treating mental illness. Although recent whole-brain models can reproduce individual brain activity patterns, they largely function as descriptive simulators rather than mechanistic, intervention-capable systems. Here we present an …

de, cn, hk, fr, gb, ch, nz, ie, nl (code pays fourni par la source)

Cu2O-decorated MoS2 nanoflowers with enhanced specific recognition for glutathione and its ultrasnsitive electrochemical detection

Yupei Yang, Di Wu, Juyun He, Qibao Zheng et autres

cn (code pays fourni par la source)

Carminic acid/ferric ion self assembled multienzyme mimetic nanodrug with concurrent photothermal/anti-inflammatory activity to prevent breast cancer metastasis

Mingcheng Wang, Huixi Yi, Qibao Zheng, Muhammad Adnan Younis et autres

The high metastatic rate of breast tumor is the prominent reason of its poor prognosis, while the inflammatory microenvironment of tumor tissues further promoted tumor metastasis. Although photothermal therapy (PTT) displays high antitumor efficacy, the rise of inflammation-induced reactive oxygen species (ROS) …

cn, us (code pays fourni par la source)

DTBIA: An Immersive Visual Analytics System for Brain-Inspired Research

Jun-Hsiang Yao, Mingzheng Li, Jiayi Liu, Yuxiao Li et autres

The Digital Twin Brain (DTB) is an advanced artificial intelligence framework that integrates spiking neurons to simulate complex cognitive functions and collaborative behaviors. For domain experts, visualizing the DTB's simulation outcomes is essential to understanding complex cognitive activities. However, this task poses …

cn, us, hk (code pays fourni par la source)

Simulation and assimilation of the digital human brain

Wenlian Lu, Xin Du, Jiexiang Wang, Longbin Zeng et autres

cn, gb (code pays fourni par la source)

Mitigating critical nodes in brain simulations via edge removal

Xin Du, Zhihui Lu, Yang Ji-rui, Shih-Chia Huang et autres

cn, tw (code pays fourni par la source)

The digital twin of the human brain: Simulation and assimilation

Jianfeng Feng, Wenlian Lu, Longbin Zeng, Jiexiang Wang et autres

cn, gb (code pays fourni par la source)

Imitating and exploring the human brain's resting and task-performing states via brain computing: scaling and architecture

Wenlian Lu, Longbin Zeng, Jiexiang Wang, Shitong Xiang et autres

A computational human brain model with the voxel-wise assimilation method was established based on individual structural and functional imaging data. We found that the more similar the brain model is to the biological counterpart in both scale and architecture, the more similarity …

cn, gb (code pays fourni par la source)

Digital Twin Brain: a simulation and assimilation platform for whole human brain

Wenlian Lu, Longbin Zeng, Xin Du, Wenyong Zhang et autres

In this work, we present a computing platform named digital twin brain (DTB) that can simulate spiking neuronal networks of the whole human brain scale and more importantly, a personalized biological brain structure. In comparison to most brain simulations with a homogeneous …

DTBVis: An interactive visual comparison system for digital twin brain and human brain

Yuxiao Li, Xinhong Li, Siqi Shen, Longbin Zeng et autres

The digital twin brain (DTB) computing model from brain-inspired computing research is an emerging artificial intelligence technique, which is realized by a computational modeling approach of hardware and software. It can achieve various cognitive abilities and their synergistic mechanisms in a manner …

cn (code pays fourni par la source)