Xinchao You

Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke

Lei Xiang, Yanfeng Lou, Lingyu Liu, Yuanling Liu et autres

Increasing evidence suggests that features of the gut microbiota correlate with ischemic stroke. However, the specific characteristics of the gut microbiota in patients suffering different types of ischemic stroke, or recovering from such strokes, have rarely been studied, and potential microbiotic predictors …

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Recombinant Matrix Metalloproteinase-9 Induces Ventricular Remodeling By Up-Regulating Angiotensin II

Lu-yuan Luo, Si-qi Gu, Wan-xing Zhou, Lizhi Chen et autres

Abstract Objective To study the effect of matrix metalloproteinase-9 (MMP-9) on ventricular remodeling and involvement of angiotensin II (Ang II). Methods Thirty-six adult male Wistar rats were randomly divided into control (n = 12), MMP-9 (n = 12), and MMP-9 + olmesartan …

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Si‐Wu‐Tang Alleviates Nonalcoholic Fatty Liver Disease via Blocking TLR4‐JNK and Caspase‐8‐GSDMD Signaling Pathways

Yaxing Zhang, Ge Zhou, Zifeng Chen, Weibing Guan et autres

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has high global prevalence; however, the treatments of NAFLD are limited due to lack of approved drugs. METHODS: Mice were randomly assigned into three groups: Control group, NAFLD group, NAFLD plus Si-Wu-Tang group. A NAFLD mice …

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H2 Protects Against Lipopolysaccharide-Induced Cardiac Dysfunction via Blocking TLR4-Mediated Cytokines Expression

Sihua Tan, Zhiyuan Long, Xiangping Hou, Yujie Lin et autres

BACKGROUND AND PURPOSE: Septic cardiomyopathy, which is one of the features of multi-organ dysfunction in sepsis, is characterized by ventricular dilatation, reduction in ejection fraction and reduced contractility, and if severe, can lead to death. To date, there is no specific therapy …

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Synthesized natural peptides from amphibian skin secretions increase the efficacy of a therapeutic vaccine by recruiting more T cells to the tumour site

Xuan Pan, Bowei Ma, Xinchao You, Jialing Wu et autres

BACKGROUND: Therapeutic vaccines against cervical cancer remain ineffective. Previously, we demonstrated that blocking the signalling of a cytokine, interleukin 10, at the time of immunisation elicited significantly higher numbers of antigen specific T cells and inhibited tumour growth in mice. RESULTS: In …

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Iodine-125 labeled Australian frog tree host-defense peptides caerin 1.1 and 1.9 better inhibit human breast cancer cells growth than the unlabeled peptides. 125I-caerin 1.9 may better be used for the treatment of breast cancer.

Jianwei Yuan, Xinchao You, Guoying Ni, Tianfang Wang et autres

OBJECTIVE: I) can be labeled to caerin 1.9 peptide and if this peptide is bioactive for breast cancer cells treatment. SUBJECTS AND METHODS: I labeled caerin 1.9 peptide was further studied in mice. RESULTS: I and also than unlabeled caerin 1.9. Additionally, …

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Estrogen stimulated migration and invasion of estrogen receptor-negative breast cancer cells involves an ezrin-dependent crosstalk between G protein-coupled receptor 30 and estrogen receptor beta signaling

Kewen Zhou, Peng Sun, Yaxing Zhang, Xinchao You et autres

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