Gülçin Şahingöz Erdal

Association of Myeloid Derived Suppressor Cells and Immunosuppressive Elements with Disease and Prognosis in Pancreatic Adenocarcinoma

Gülçin Şahingöz Erdal, Nilgün Işıksaçan, Alpen Yahya Gümüşoğlu, Hamit Ahmet Kabuli et autres

The aim of this study was to evaluate the roles of myeloid-derived suppressor cells (MDSCs) and immunosuppressive cytokines in different patient groups with pancreatic adenocarcinoma (PAC).Inoperable advanced-stage patients, operable patients (evaluated as preoperative and postoperative), and healthy controls were included.Peripheral blood MDSC …

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The Dual Role of Mesenchymal Stem Cells in Cancer: From Immune Modulation to Therapy Resistance

Gülçin Şahingöz Erdal, Tamay Seda Taşçı, Nilgün Işıksaçan

Mesenchymal stem cells (MSCs) have emerged as key modulators within the tumor microenvironment due to their ability to influence immune responses, tumor progression, and therapeutic resistance. While some evidence suggests anti-tumorigenic properties, numerous studies have revealed that MSCs can also promote immune …

Advanced Glycation End Products: A Promising Prognostic Indicator in Breast Cancer Patients

Gülçin Şahingöz Erdal, Nilgün Işıksaçan, Murat Çikot, Mustafa Yaman et autres

Introduction: Advanced glycation end products (AGEs) form through long-term reactions between proteins/lipids and sugars, accumulating in tissues and contributing to disease. AGEs are linked to cancer progression, with studies showing associations with colon and pancreatic cancer. Methods: This study investigates the relationship …

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Nivolumab Efficacy and Safety in Cancer Patients with Renal Dysfunction

Ezgi Değerli, Mesut Yılmaz, Gülçin Şahingöz Erdal, Rumeysa Çolak et autres

Abs tractAim: Immune checkpoint inhibitors have transformed cancer treatment; however, clinical trials often exclude patients with renal dysfunction.This study aimed to evaluate the efficacy and safety of nivolumab in this population, addressing the limited available data.Methods: A retrospective cross-sectional study was conducted …

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The Role of Glyoxal, an Advanced Glycation Product, in Diabetic and Non-diabetic Patients with COVID-19

Nilgün Işıksaçan, Gülçin Şahingöz Erdal, Duygu Teksöz, Pınar Kasapoğlu et autres

Objective: The aim of this study was to investigate the effect on coronavirus disease-2019 (COVID-19) of glyoxal (GO), which is a precursor of advanced glycation end-products, in diabetic and nondiabetic patients, treated in hospital for COVID-19 who were of similar age and …

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Change in the neutrophil‐lymphocyte ratio may predict early recurrence in operated bladder cancer

Rumeysa Çolak, Gökmen Umut Erdem, Caner Kapar, İlkay Gültürk et autres

BACKGROUND: Recurrence develops in 50% of operated bladder cancer patients. It is important to detect recurrence in advance, and there is no prognostic reliable biomarker for bladder cancer. OBJECTIVE: The aim of this study is to show that changes in hematological parameters …

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The effect of mesenchymal stem cells administration on DNA repair gene expressions in critically ill COVID-19 patients: prospective controlled study

Nilgün Işıksaçan, Gökhan Adaş, Pınar Kasapoğlu, Zafer Çukurova et autres

When the studies are evaluated, immunomodulatory effect of MSCs, administration in critically ill patients, obstacle situations in use and side effects, pulmonary fibrosis prevention, which stem cells and their products, regeneration effect, administration route, and dosage are listed under the main heading …

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The Relationship of Serum Beta Defensin-2 and Surfactant Protein A and B Levels with the Clinical Course and Prognosis of COVID-19 Infection

Gülçin Şahingöz Erdal, Pınar Kasapoğlu, Tamay Seda Taşçı, Ramazan Korkusuz et autres

Aim: Defensin and surfactant-related peptides are antimicrobial peptides that play an essential role in the natural host defense against micro-organisms. The objective is to compare the serum beta-defensin 2 (ß-def2), serum surfactant protein-A (sSPA) and B (sSPB) levels and respiratory surfactant protein …

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Cancer Treatment Through Immunological Pathways: A Great Hope for Every Type of Cancer and Every Patient

Gülçin Şahingöz Erdal, Pınar Atar, Nilgün Işıksaçan

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The Relationship of Serum Beta Defensin-2 and Surfactant Protein A and B Levels with the Clinical Course and Prognosis of COVID-19 Infection

Gülçin Şahingöz Erdal, Pınar Kasapoğlu, Tamay Seda Taşçı, Ramazan Korkusuz et autres

Aim: Defensin and surfactant-related peptides are antimicrobial peptides that play an essential role in the natural host defense against micro-organisms.The objective is to compare the serum beta-defensin 2 (ß-def2), serum surfactant protein-A (sSPA) and B (sSPB) levels and respiratory surfactant protein A …

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Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019

Dilay Karabulut, Cennet Çiriş Yıldız, Umut Karabulut, Ersan Oflar et autres

Objective: This study aimed to evaluate cardiac myosin-binding protein C (cMyBP-C) levels in patients with COVID-19.Materials and Methods: Overall, 187 patients were enrolled in the study. Patients with mild–moderate and severe–critical illness constituted groups 0 and 1, respectively.Results: Admission to the intensive …

Efficacy of Capecitabine and Temozolomide Regimen in Neuroendocrine Tumors: Data From the Turkish Oncology Group

Çağlar Ünal, Abdulmunir Azizy, Senem Karabulut, Didem Taştekin et autres

INTRODUCTION: This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines of treatment in patients with metastatic neuroendocrine tumors (NETs). METHODS: We conducted a multicenter retrospective study analyzing the data of 308 patients with metastatic …

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