The Dual Role of Mesenchymal Stem Cells in Cancer: From Immune Modulation to Therapy Resistance

Le résumé fourni par la source

Mesenchymal stem cells (MSCs) have emerged as key modulators within the tumor microenvironment due to their ability to influence immune responses, tumor progression, and therapeutic resistance. While some evidence suggests anti-tumorigenic properties, numerous studies have revealed that MSCs can also promote immune evasion, enhance epithelial-mesenchymal transition, and support tumor growth. Furthermore, MSC-derived exosomes and secreted factors may contribute to resistance against chemotherapy, targeted therapies, and immunotherapies. This chapter will explore the dual role of MSCs in cancer biology, with a particular focus on their interactions with immune cells such as myeloid-derived suppressor cells (MDSCs), Tregs, macrophages, and natural killer (NK) cells, as well as their involvement in drug resistance mechanisms. Additionally, recent advances in engineering MSCs as therapeutic delivery systems will be discussed, highlighting their potential—and limitations—in future cancer treatments. Through a comprehensive review of current literature, this chapter aims to provide an updated and critical insight into the multifaceted role of MSCs in solid tumors.

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