Jiaxin Song

New Immunological Insights into Bisphosphonate-Related Osteonecrosis of the Jaw: A Multidimensional Reappraisal from Molecular Switches to Clinical Phenotypes

Yao Li, Shengao Qin, Jiaqi Wang, Zhaochen Shan et autres

Bisphosphonates (BPs) are cornerstone therapeutic agents for the management of metabolic bone disorders and skeletal complications associated with malignant tumors. However, their long-term administration is accompanied by the risk of developing bisphosphonate-related osteonecrosis of the jaw (BRONJ). In recent years, the pathogenesis …

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Text data mining and customer demand insight for port logistics marketing based on the transformer model

Linyuan Xu, Jiaqi Zhang, Jiaxin Song, Yijia Chen et autres

To address the issue of low efficiency and insufficient accuracy of traditional customer demand insight methods in the context of intensified competition in the port logistics industry, this paper focuses on the research of customer demand insight using port logistics marketing text …

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SATB1 regulates the osteogenic differentiation of PDLSCs via HDAC1 mediated non-histone protein deacetylation and ubiquitination mechanism and through p38 MAPK pathway under hydrogen peroxide-induced senescent conditions

Meijun Hu, Jiaxin Song, Wanhao Yan, Yu Jiang et autres

Periodontitis is a chronic inflammatory disease that affects the supporting tissues around teeth. A reduction in the pluripotency of periodontal ligament stem cells (PDLSCs) has been identified as a pivotal factor in age-related alveolar bone loss. This study investigated the effects of …

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CD27 Neutralization Attenuates Rheumatoid Arthritis by Suppressing

Anghan Lu, Luqiao Pu, Yadan Tian, Jiaxin Song et autres

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Genome-wide identification of small GTPase gene family members in Lentinula edodes and the roles of LeRho1 in biotic and abiotic stress responses

Jiaxin Song, Tianwen Zhu, Ruiping Xu, Hairong Yin et autres

ABSTRACT Lentinula edodes ( L. edodes ) is the largest proportion of edible mushrooms in China. However, the yield is highly susceptible to environmental stress. Factors such as high-temperature stress, low-temperature stress, Trichoderma infection, heavy metal stress, and light exposure all impact …

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Lipid Metabolism and Membrane Remodeling Drive Sclerotium Formation in Morchella eximia: Insights from Integrated Transcriptomics and Metabolomics

Chunmou Wei, Jimeng Li, Z.W. MO, Wei Liu et autres

Sclerotium formation represents a critical transition phase in the life cycle of morel, shifting from vegetative growth to dormant structures. The capacity for sclerotium formation directly influences the yield and stability of artificial cultivation. To elucidate the molecular regulatory mechanisms underlying this …

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The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid govern thermotolerance in Lentinula edodes mycelia subjected to heat stress

Jiaxin Song, Jiayue Chen, Yang Xiao, Yan Hong Zhou et autres

ABSTRACT Heat stress poses a significant constraint on the annual production of Lentinula edodes (L. edodes ), a challenge that has been intensified by global warming. Previous studies have established a close relationship between intracellular indole-3-acetic acid (IAA) content and heat tolerance …

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Inhibition of miR-615-3p enhances dentinogenesis in scaps via PVT1-mediated mitochondrial regulation

Haoqing Yang, Yishu Huang, Jiaxin Song, Xiao Han

BACKGROUND: Mesenchymal stem cells (MSCs) are critical for dental tissue regeneration, yet their differentiation potential is tightly regulated by microRNAs (miRNAs). This study aimed to investigate the role of miR-615-3p in regulating odontogenic differentiation in stem cells from the apical papilla (SCAPs), …

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LINC01013 reverses bisphosphonate-impaired osteogenic differentiation of JBMMSCs by regulating intracellular translocation of ILF3

Jiaxin Song, Wanqing Wang, Xuanhe Feng, Haoqing Yang et autres

BACKGROUND: Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a serious complication associated with bisphosphonate (BP) therapy. Enhancement of the osteogenic differentiation of human jaw bone marrow mesenchymal stem cells (JBMMSCs) is a key issue in the treatment of BRONJ. In this study, …

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Transcriptome analysis of cerebral organoids reveals the potential of walnut oil unsaponifiable matter to benefits neural development and cognition

Junjun Zhou, Dan Hong, Liang Yue, Jiaxin Song et autres

Abstract The impacts of dietary nutrient intakes on brain development during the early life have been investigated extensively. As walnuts have been historically considered beneficial for cognition, this study was set to determine the mechanism by which unsaponifiable matter (USM) of walnut …

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Betaine Alleviates Bisphosphonate-Related Osteonecrosis of the Jaw by Rescuing BMSCs Function in an m6A-METTL3-Dependent Manner

Yizhou Jin, Jiaxin Song, Xiao Han, Zhipeng Fan

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is one of the side effects of bisphosphonate (BP) administration. Despite some preventive measures having been suggested, a definitive and effective treatment strategy for BRONJ remains to be established. Recent evidence has indicated that BPs dramatically …

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Experimental and numerical simulation study on the interfacial shear performance of UHPECC reinforced existing brick wall

Xue Feixiang, Wei Liang Huang, Wu Yingxiong, Jiaxin Song et autres

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