JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks
Michael Van Meter, Matthew D. Simon, Gregory Tombline, Alfred May et autres
1 citation
Cell Reports
Michael Van Meter
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37Publications signalées
3179Citations signalées
0Affiliations récentes
Les domaines associés
Sirtuins and Resveratrol in MedicinePARP inhibition in cancer therapyDNA Repair MechanismsAcute Myeloid Leukemia ResearchRNA regulation and disease
Les publications récentes
Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes
Michael D. Kessler, Amy Damask, Sean O’Keeffe, Nilanjana Banerjee et autres
us (code pays fourni par la source)
0 citations
Nature
Author Correction: Common and rare variant associations with clonal haematopoiesis phenotypes
Michael D. Kessler, Amy Damask, Sean O’Keeffe, Nilanjana Banerjee et autres
us (code pays fourni par la source)
0 citations
Nature
Erratum To: A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew S. Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley et autres
12 citations
The EMBO Journal
Common and rare variant associations with clonal haematopoiesis phenotypes
Michael D. Kessler, Amy Damask, Sean O’Keeffe, Nilanjana Banerjee et autres
us (code pays fourni par la source)
319 citations
Nature
Pre-T cell receptor signaling drives leukemogenesis and is a therapeutic target in T-cell acute lymphoblastic leukemia
Michael Van Meter, Jie Gao, Wei Wang, Arthur Kunz et autres
us (code pays fourni par la source)
0 citations
Research Square
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley et autres
Sirtuin 6 (SIRT6) is a deacylase and mono‐ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in aging and metabolism regulation. Targeted sequencing of SIRT6 locus in a population of 450 Ashkenazi Jewish (AJ) centenarians and 550 AJ individuals without …
us, il (code pays fourni par la source)
69 citations
The EMBO Journal
Exome sequencing of 628,388 individuals identifies common and rare variant associations with clonal hematopoiesis phenotypes
Michael D. Kessler, Amy Damask, Sean O’Keeffe, Michael Van Meter et autres
Abstract Clonal hematopoiesis (CH) refers to the expansion of certain blood cell lineages and has been associated with aging and adverse health outcomes. Here, we use exome sequence data on 628,388 individuals to identify 40,208 carriers of clonal hematopoiesis of indeterminate potential …
us (code pays fourni par la source)
21 citations
medRxiv
A rare human centenarian variant of SIRT6 enhances genome stability and interaction with Lamin A
Matthew Simon, Jiping Yang, Jonathan Gigas, Eric J. Earley et autres
SUMMARY Sirtuin 6 (SIRT6) is a deacylase and mono-ADP ribosyl transferase (mADPr) enzyme involved in multiple cellular pathways implicated in the regulation of aging and metabolism. Targeted sequencing identified a SIRT6 allele containing two linked substitutions (N308K/A313S) as enriched in Ashkenazi Jewish …
us, il (code pays fourni par la source)
3 citations
bioRxiv (Cold Spring Harbor Laboratory)
The Emergency Medicine Group Standardized Letter of Evaluation as a Workplace-based Assessment: The Validity Is in the Detail
Jeffrey J. Love, Christopher Doty, Jessica Smith, Nicole M. Deiorio et autres
INTRODUCTION: Interest is growing in specialty-specific assessments of student candidates based on clinical clerkship performance to assist in the selection process for postgraduate training. The most established and extensively used is the emergency medicine (EM) Standardized Letter of Evaluation (SLOE), serving as …
us (code pays fourni par la source)
24 citations
Western Journal of Emergency Medicine
Therapeutic targeting of Notch signaling and immune checkpoint blockade in a spontaneous, genetically heterogeneous mouse model of T-cell acute lymphoblastic leukemia
Jie Gao, Michael Van Meter, Susana Hernández, Guoying Chen et autres
ABSTRACT T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic cancer derived from the malignant transformation of T-cell progenitors. Outcomes remain poor for T-ALL patients who have either primary resistance to standard-of-care chemotherapy or disease relapse. Notably, there are currently no targeted …
us (code pays fourni par la source)
11 citations
Disease Models & Mechanisms
LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation
Matthew Simon, Michael Van Meter, Julia Ablaeva, Zhonghe Ke et autres
us, il (code pays fourni par la source)
521 citations
Cell Metabolism
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