Giorgio Santoni

mRNA expression, tumor heterogeneity, and response to therapy in patients with advanced renal cell carcinoma treated with immune-based combinations (ARON-1α)

Cristina Aguzzi, Simona De Summa, Javier Molina‐Cerrillo, Teresa Alonso‐Gordoa et autres

Background Renal Cell Carcinoma (RCC) represents a spectrum of tumors, characterized by heterogeneous growth patterns, histology and response to immune-based combinations. Objectives The aim of the present retrospective analysis was to investigate the mRNA expression of 32 genes associated with RCC carcinogenesis …

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Adenosine A 3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

Maria Beatrice Morelli, Andrea Spinaci, Chang Cui, Rosaria Volpini et autres

Prostate cancer (PCa) is one of the most common cancers in men, and for patients with PCa that cannot be surgically resected or treated, androgen suppression therapy often results in significant adverse effects. Recent studies have shown that A3 adenosine receptors (A …

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Author response for "Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study"

Maria Beatrice Morelli, Andrea Spinaci, Chang Cui, Rosaria Volpini et autres

Correction: Luongo et al. Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers 2020, 12, 2774

Margherita Luongo, Oliviero Marinelli, Laura Zeppa, Cristina Aguzzi et autres

There was an error in the original publication [...].

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Fibronectin Receptors on NK Cells

Angela Santoni, Angela Gismondi, Gabriella Palmieri, Stefania Morrone et autres

Induction and regulation of the immune response and several effector functions of leukocytes require cell-cell contact and adhesive interactions. Adhesion is also a mandatory step for leukocytes passing through the vascular endothelium and migrating to the site of infection or inflammation. Adhesion …

In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma

Laura Zeppa, Cristina Aguzzi, Maria Beatrice Morelli, Oliviero Marinelli et autres

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis and high mortality rates. Therefore, it is necessary to identify new targets and therapeutic strategies to improve the prognosis of patients with PDAC. Integrative therapies are increasingly being used to boost the efficacy of …

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Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma

Cristina Aguzzi, Laura Zeppa, Maria Beatrice Morelli, Oliviero Marinelli et autres

Multiple myeloma (MM) is a blood cancer caused by uncontrolled growth of clonal plasmacells. Bone disease is responsible for the severe complications of MM and is caused by myeloma cells infiltrating the bone marrow and inducing osteoclast activation. To date, no treatment …

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Cannabigerol Induces Autophagic Cell Death by Inhibiting EGFR-RAS Pathways in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Laura Zeppa, Cristina Aguzzi, Maria Beatrice Morelli, Oliviero Marinelli et autres

Pancreatic ductal adenocarcinoma (PDAC) is the most frequent infiltrating type of pancreatic cancer. The poor prognosis associated with this cancer is due to the absence of specific biomarkers, aggressiveness, and treatment resistance. PDAC is a deadly malignancy bearing distinct genetic alterations, the …

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Cannabigerol Induces Autophagic-Cell Death by Inhibiting EGFR-RAS-Pathways in Human Pancreatic Ductal Adenocarcinoma Cell Lines

Laura Zeppa, Cristina Aguzzi, Maria Beatrice Morelli, Oliviero Marinelli et autres

Pancreatic Ductal Adenocarcinoma (PDAC) is the most frequent infiltrating type of pancreatic cancer. The poor prognosis is due to the absence of specific biomarkers, aggressiveness and treatment resistance. PDAC is a deadly malignancy bearing distinct genetic alterations, the most common being those …

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Calcium influx, oxidative stress, and apoptosis induced by TRPV1 in chronic myeloid leukemia cells: Synergistic effects with imatinib

Federica Maggi, Maria Beatrice Morelli, Cristina Aguzzi, Laura Zeppa et autres

Introduction: Calcium flux is the master second messenger that influences the proliferation–apoptosis balance. The ability of calcium flux alterations to reduce cell growth makes ion channels interesting targets for therapy. Among all, we focused on transient receptor potential vanilloid 1, a ligand-gated …

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Role of Clock Genes and Circadian Rhythm in Renal Cell Carcinoma: Recent Evidence and Therapeutic Consequences

Matteo Santoni, Javier Molina‐Cerrillo, Giorgio Santoni, Elaine T. Lam et autres

Circadian rhythm regulates cellular differentiation and physiology and shapes the immune response. Altered expression of clock genes might lead to the onset of common malignant cancers, including Renal Cell Carcinoma (RCC). Data from Cancer Genome Atlas (TCGA) indicate that clock genes PER1-3, …

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TRPML2 Mucolipin Channels Drive the Response of Glioma Stem Cells to Temozolomide and Affect the Overall Survival in Glioblastoma Patients

Maria Beatrice Morelli, Massimo Nabissi, Consuelo Amantini, Federica Maggi et autres

The survival of patients with glioblastoma (GBM) is poor. The main cause is the presence of glioma stem cells (GSCs), exceptionally resistant to temozolomide (TMZ) treatment. This last may be related to the heterogeneous expression of ion channels, among them TRPML2. Its …

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