Cristina Aguzzi

Advanced technology for purification of N-alkylamides from Acmella oleracea (L.) R.K. Jansen and development of innovative, safe and eco-friendly larvicidal extracts

Giada Trebaiocchi, Marta Ferrati, Eleonora Spinozzi, Cecilia Baldassarri et autres

The recent increase of insecticide resistance highlighted an urgent need for innovative products from natural sources. The aim is to reduce the excessive use of synthetic pesticides boosting resistance development in mosquitoes and causing serious threats to human health and environment [ …

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Synthesis, Structural Studies, and Biological Evaluation of Copper(I) and Copper(II) Complexes Supported by Bis(pyrazol-1-yl)acetate Ligand Functionalized with Amantadine for the Treatment of Glioblastoma

Sofia Migani, Giuseppina Bozzuto, Annarica Calcabrini, Marisa Colone et autres

This paper reports the synthesis, structural characterization, and biological evaluation of a novel series of CuI and CuII complexes supported by an amantadine-functionalized bis(pyrazol-1-yl)acetate ligand (LAd) as potential anticancer agents for the treatment of glioblastoma (GBM). Comprehensive spectroscopic and structural investigations, including …

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Integrative Use of Cannabidiol, Melatonin, and Oxygen–Ozone Therapy in Triple-Negative Breast Cancer with Lung and Mediastinal Metastases. A Case Report

Cristina Aguzzi, Paola Zuccoli, A. Fanelli, Alessandra Mammone et autres

Background and Clinical Significance: Breast cancer is the most frequent malignancy in women. Metastatic breast cancer is considered a treatable but incurable condition, with a median overall survival of only 2–3 years. Among its subtypes, triple-negative breast cancer (TNBC) accounts for a …

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Integrative Use of Cannabidiol, Melatonin, and Oxygen-Ozone Therapy in Triple-Negative Breast Cancer with Lung and Mediastinal Metastases: A Case Report

Cristina Aguzzi, Paola Zuccoli, A. Fanelli, Alessandra Mammone et autres

Background and Clinical Significance: Breast cancer is the most frequent malignancy in women. Advanced metastatic breast cancer is considered a treatable but incurable condition, with a median overall survival of only 2-3 years. Among its subtypes, triple-negative breast cancer (TNBC) accounts for …

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Synthesis, structural characterization, and investigation of anti-glioblastoma activity of copper complexes supported by bis(pyrazol-1-yl)acetate ligands functionalized with memantine

Miriam Caviglia, Fabio Del Bello, Carlo Santini, Sofia Migani et autres

ligand. Among all Cu complexes tested, compounds 4 and 5 exhibited potent antiproliferative and cytotoxic effects in U87, T98, and U251 glioma cell lines. These effects were associated with increased reactive oxygen species (ROS) production and mitochondrial dysfunction, as evidenced by mitochondrial …

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mRNA expression, tumor heterogeneity, and response to therapy in patients with advanced renal cell carcinoma treated with immune-based combinations (ARON-1α)

Cristina Aguzzi, Simona De Summa, Javier Molina‐Cerrillo, Teresa Alonso‐Gordoa et autres

Background Renal Cell Carcinoma (RCC) represents a spectrum of tumors, characterized by heterogeneous growth patterns, histology and response to immune-based combinations. Objectives The aim of the present retrospective analysis was to investigate the mRNA expression of 32 genes associated with RCC carcinogenesis …

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Exploring the Therapeutic Potential of Natural Compounds and Plant Extracts in Human Health

Laura Zeppa, Cristina Aguzzi, Maria Beatrice Morelli

A growing body of evidence supports the various potential advantages of plant extracts and plant extract-based products in promoting human health and addressing a broad range of pathological conditions [...].

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A Study of the Effects of Oleuropein and Polydatin Association on Muscle and Bone Metabolism

Maria Beatrice Morelli, Cristina Aguzzi, Riccardo Rascioni, Fiorenzo Mignini

Sarcopenia and osteoporosis are age-related musculoskeletal pathologies that often develop in parallel, and numerous studies support the concept of a bone-muscle unit, where deep interaction between the two tissues takes place. In Mediterranean areas, the lowest incidence of osteoporosis within Europe is …

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Adenosine A 3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

Maria Beatrice Morelli, Andrea Spinaci, Chang Cui, Rosaria Volpini et autres

Prostate cancer (PCa) is one of the most common cancers in men, and for patients with PCa that cannot be surgically resected or treated, androgen suppression therapy often results in significant adverse effects. Recent studies have shown that A3 adenosine receptors (A …

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Author response for "Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study"

Maria Beatrice Morelli, Andrea Spinaci, Chang Cui, Rosaria Volpini et autres

Correction: Luongo et al. Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers 2020, 12, 2774

Margherita Luongo, Oliviero Marinelli, Laura Zeppa, Cristina Aguzzi et autres

There was an error in the original publication [...].

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In Vitro and In Vivo Effects of Melatonin‐Containing Combinations in Human Pancreatic Ductal Adenocarcinoma

Laura Zeppa, Cristina Aguzzi, Maria Beatrice Morelli, Oliviero Marinelli et autres

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) has poor prognosis and high mortality rates. Therefore, it is necessary to identify new targets and therapeutic strategies to improve the prognosis of patients with PDAC. Integrative therapies are increasingly being used to boost the efficacy of …

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