Domenic J. Reda

Vancomycin Taper and Pulse or Fidaxomicin for Recurrent C. difficile Infection

Stuart Johnson, Dale N. Gerding, Curtis J. Donskey, Hua Feng et autres

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548. A Randomized, Double-blind, Controlled Trial of Vancomycin Taper/Pulse and Fidaxomicin compared to Vancomycin for Treatment of a First or Second Recurrence of Clostridioides difficile Infection

Stuart Johnson, Dale N Gerding, Curtis Donskey, Hua Feng et autres

Abstract Background Vancomycin taper followed by pulse and fidaxomicin are two common treatments for recurrent C. difficile infection (rCDI) but they have not been formally compared.Kaplan-Meier plot of days from symptom resolution to recurrences of diarrhea [A] and recurrent C. difficile infection …

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Centralized Quality Assurance of Stereotactic Body Radiation Therapy for the Veterans Affairs Cooperative Studies Program Study Number 2005: A Phase 3 Randomized Trial of Lung Cancer Surgery or Stereotactic Radiotherapy for Operable Early-Stage Non-Small Cell Lung Cancer (VALOR)

Timothy Ritter, Robert Timmerman, Hena I. Hanfi, Hairong Shi et autres

PURPOSE: The phase 3 Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy study implemented centralized quality assurance (QA) to mitigate risks of protocol deviations. This report summarizes the quality and compliance of the first 100 participants treated with stereotactic body radiation therapy …

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Protocol for the Veterans Affairs Cooperative Studies Program Study Number 2005

Drew Moghanaki, Tomer Z. Karas, Robert Timmerman, Robert B. Cameron et autres

Background: Standard-of-care treatment options for stage I non-small cell lung cancer (NSCLC) include surgery and stereotactic body radiation therapy (SBRT). Notwithstanding a lack of prospective evidence demonstrating superior long-term survival with either of these treatments, evidence-based guidelines currently recommend only surgery for …

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Efficacy and Safety of Mifepristone in the Treatment of Male US Veterans With Posttraumatic Stress Disorder

Julia A. Golier, Xue Li, Marcel Bizien, Robin A. Hurley et autres

Importance: To date, no psychopharmacologic treatment has been found to be uniformly effective in veterans with posttraumatic stress disorder (PTSD); novel targets and approaches are needed to treat this disabling disorder. Objective: To examine whether treatment with the glucocorticoid receptor antagonist mifepristone …

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Defining optimal treatment for recurrent Clostridioides difficile infection (OpTION study): A randomized, double-blind comparison of three antibiotic regimens for patients with a first or second recurrence

Stuart Johnson, Dale N. Gerding, Xue Li, Domenic J. Reda et autres

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Development of a new adapted QuinteT Recruitment Intervention (QRI-Two) for rapid application to RCTs underway with enrolment shortfalls—to identify previously hidden barriers and improve recruitment

Jenny Donovan, Marcus Jepson, Leila Rooshenas, Sangeetha Paramasivan et autres

BACKGROUND: Many randomised controlled trials (RCTs) struggle to recruit, despite valiant efforts. The QRI (QuinteT Recruitment Intervention) uses innovative research methods to optimise recruitment by revealing previously hidden barriers related to the perceptions and experiences of recruiters and patients, and targeting remedial …

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Effect of Pulsed Low-Intensity Ultrasonography on Symptom Relief and Tibiofemoral Articular Cartilage Thickness Among Veterans Affairs Enrollees With Knee Osteoarthritis

Allen D. Sawitzke, Kimberly Carlson, Marcel Bizien, Mathew Leiner et autres

Importance: Osteoarthritis (OA) is a major cause of disability in the US, with no approved treatments to slow progression, but animal models suggest that pulsed low-intensity ultrasonography (PLIUS) may promote cartilage growth. Objective: To evaluate the efficacy of PLIUS in providing symptom …

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Predictors of multi-domain cognitive decline following DBS for treatment of Parkinson's disease

Johannes Rothlind, Michele K. York, Ping Luo, Kim Carlson et autres

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A cohort study of neuropsychological functioning in spouses of U.S. Gulf War veterans

Rosemary Toomey, Renee Alpern, Domenic J. Reda, Dewleen G. Baker et autres

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Pentoxifylline in diabetic kidney disease (VA PTXRx): protocol for a pragmatic randomised controlled trial

David J. Leehey, Kimberly Carlson, Domenic J. Reda, I.R. Craig et autres

INTRODUCTION: Diabetic kidney disease (DKD) is the most frequent cause of end-stage renal disease (ESRD) in the USA and worldwide. Recent experimental and clinical data suggest that the non-specific phosphodiesterase inhibitor pentoxifylline (PTX) may decrease progression of chronic kidney disease. However, a …

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Generalizability of heterogeneous treatment effects based on causal forests applied to two randomized clinical trials of intensive glycemic control

Sridharan Raghavan, Kevin Josey, Gideon Bahn, Domenic J. Reda et autres

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