James P. DeLany

2514-P: Older Adults with Prediabetes or Type 2 Diabetes Experience Poor Recovery of Muscle Power and Torque but Not Volume following 10 Days of Bed Rest

CHRISTIAN ELLIEHAUSEN, SOFHIA V. RAMOS, J. Matthew Hinkley, Fanchao Yi et autres

Introduction and Objective: Older adults with pre-diabetes (p-D) or type 2 diabetes (T2D) may be vulnerable to an accelerated loss of muscle mass and function due to poor recovery following physical inactivity. To test this paradigm, we conducted a 10-day bed rest …

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2521-P: Physical Inactivity Induced by Bed Rest Reduces Muscle but Not Hepatic or Adipose Tissue Insulin Sensitivity in Older Adults with or without Pre- or Type 2 Diabetes

CHRISTIAN ELLIEHAUSEN, Justine M. Mucinski, SOFHIA V. RAMOS, J. Matthew Hinkley et autres

Introduction and Objective: Older adults with pre-diabetes or type 2 diabetes experience hospitalization and bed rest more frequently than healthy older adults. However, the impact of physical inactivity induced by bed rest on insulin sensitivity in older adults with pre- or type …

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A multiplexed targeted mass spectrometric assay for quantifying obesity- associated biomarkers in human plasma

Tai‐Tu Lin, Panshak Dakup, Athena Schepmoes, Thomas Fillmore et autres

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Caloric restriction and time-restricted eating in older adults with overweight or obesity: The Health, Aging, and Later-Life Outcomes Pilot Study

Denise K. Houston, Jason Fanning, Barbara J Nicklas, James P. DeLany et autres

BACKGROUND: In animal models, caloric restriction (CR) and time-restricted eating (TRE) extend lifespan and healthspan; however, the long-term benefits in humans are unknown. The goal of the Health, Aging and Later-Life Outcomes Pilot (HALLO-P) was to inform the design of a definitive …

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Adaptations in Energy Expenditure Following Caloric Restriction in Older Adults

Denise K. Houston, Jason Fanning, James P. DeLany, Fang‐Chi Hsu et autres

Abstract Adaptations in components of energy expenditure (EE) occur in response to caloric restriction (CR) and contribute to the propensity for weight regain following weight loss. However, the magnitude of changes in EE following CR is not well known in older adults. …

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NB22: A Deep Learning-designed Peptide-siRNA Conjugate That Targets Lung Epithelial Cells Implicated in IPF

Kyler Lugo, Claudia P. Miller, James P. DeLany, T. F. Tracy et autres

Abstract Rationale: Idiopathic Pulmonary Fibrosis (IPF) is a progressive, restrictive pulmonary disease characterized by interstitial fibrosis. Approximately 40 thousand IPF cases & deaths are recorded each year in the United States, making IPF more rapidly lethal than many malignancies and as deadly …

Muscle Mitochondrial Respiration and Cardiorespiratory Fitness Contribute to Slower Walking Speed of Older Individuals Who Identify as Black

Paul M. Coen, Fanchao Yi, Li‐Yung Lui, Giovanna Distéfano et autres

ABSTRACT In the United States, older adults who self‐identify as Black have a disproportionately higher incidence of mobility disability compared to those who are White. Whether older adults who are Black also have lower fitness and mitochondrial energetics has not been adequately …

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A multiplex assay of leptin, resistin, and adiponectin by immunoaffinity enrichment and targeted mass spectrometry

Jie Pu, Xinxin Yang, Tai‐Tu Lin, Thomas Fillmore et autres

Background: Leptin, resistin, and adiponectin are critical adipokines involved in the pathophysiology of obesity and its related disorders, including type 2 diabetes. Although these biomarkers have historically been quantified using immunoassays, the specificity of antibody-based methods has frequently been questioned. As a …

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RACE DIFFERENCES IN WALK SPEED, CARDIORESPIRATORY FITNESS, AND MUSCLE MITOCHONDRIAL RESPIRATION

Paul M. Coen, Giovanna Distéfano, Sofhia V. Ramos, Peggy M. Cawthon et autres

Abstract Older adults who self-identify as Black have a disproportionately higher incidence of mobility disability. Whether older adults who are Black also have lower fitness and mitochondrial energetics compared to those who are White has not been adequately investigated. The Study of …

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CALORIC RESTRICTION VERSUS TIME-RESTRICTED EATING: THE HEALTH, AGING, AND LATER-LIFE OUTCOMES PILOT

Denise K. Houston, Barbara J. Nicklas, Michael E. Miller, Jason Fanning et autres

Abstract In animal models, dietary interventions including caloric restriction (CR) and time-restricted eating (TRE) extend both lifespan and healthspan. However, in humans, the long-term benefits of these diets on lifespan and healthspan, and whether benefits outweigh harms, are unknown. The goal of …

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Insulin Sensitivity and Skeletal Muscle Mitochondrial Respiration in Black and White Women With Obesity

Justine M. Mucinski, Giovanna Distéfano, John J. Dubé, Frederico G. S. Toledo et autres

OBJECTIVES: Non-Hispanic Black women (BW) have a greater risk of type 2 diabetes (T2D) and insulin resistance (IR) compared to non-Hispanic White women (WW). The mechanisms leading to these differences are not understood, and it is unclear whether synergistic effects of race …

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Preliminary field validity of ActiGraph-based energy expenditure estimation in wheelchair users with spinal cord injury

Zijian Huang, Akhila Veerubhotla, James P. DeLany, Dan Ding

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