Li‐Yung Lui

Muscle Mitochondrial Respiration and Cardiorespiratory Fitness Contribute to Slower Walking Speed of Older Individuals Who Identify as Black

Paul M. Coen, Fanchao Yi, Li‐Yung Lui, Giovanna Distéfano et autres

ABSTRACT In the United States, older adults who self‐identify as Black have a disproportionately higher incidence of mobility disability compared to those who are White. Whether older adults who are Black also have lower fitness and mitochondrial energetics has not been adequately …

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Correction to: Biomarkers of cellular senescence and major health outcomes in older adults

Steven R. Cummings, Li‐Yung Lui, Zaira Aversa, Theresa Mau et autres

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Sicherheitsprofil von subkutanem (s. c.) Efgartigimod PH20 aus klinischen Studien bei durch Immunglobulin G verursachten Autoimmunerkrankungen

A Saak, Pieter A. van Doorn, K G Gwathmey, Jan De Bleecker et autres

Hintergrund: Die Sicherheit von Efgartigimod PH20 s. c. bei generalisierter Myasthenia gravis (gMG) und chronisch-entzündlicher demyelinisierender Polyneuropathie (CIDP) wurde untersucht. Methodik: Efgartigimod PH20 s. c. wurde als Zyklus mit einer Injektion wöchentlich über vier Wochen verabreicht (gMG Studie ADAPT-SC sowie die noch …

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Investigating the role of adipose tissue in mobility and aging: design and methods of the Adipose Tissue ancillary to the Study of Muscle, Mobility, and Aging (SOMMA-AT)

Reichelle X. Yeo, Theresa Mau, Zofia Ross, Nicholas Edenhoffer et autres

BACKGROUND: Age-related changes in adipose tissue affect chronic medical diseases and mobility disability but mechanism remains poorly understood. The goal of this study is to define methods for phenotyping unique characteristics of adipose tissue from older adults. METHODS: Older adults enrolled in …

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Biomarkers of cellular senescence and major health outcomes in older adults

Steven R. Cummings, Li‐Yung Lui, Aversa Zaira, Theresa Mau et autres

The geroscience hypothesis proposes that underlying biological processes, such as the accumulation of senescent cells, have deleterious effects on multiple tissues and increase the risk of many chronic conditions with aging. Senescent cells produce heterogenous biomarkers, also called senescence-associated secretory phenotype (SASP). …

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The relationship between baseline bone mineral density and fracture incidence in the placebo groups of randomized controlled trials using individual patient data from the FNIH-ASBMR-SABRE project

Marian Schini, Li‐Yung Lui, Tatiane Vilaça, Susan K. Ewing et autres

We have proposed to the Food and Drug Administration (FDA) that treatment-related increases in total hip BMD (TH BMD) at 2 yr could be a surrogate endpoint for fracture risk reduction in clinical trials. The qualification of a surrogate includes a strong …

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THE NEUTROPHIL-LYMPHOCYTE RATIO AND WHITE BLOOD CELL COUNT ASSOCIATE WITH MUSCLE ENERGETICS AND GAIT SPEED IN SOMMA

Philip Kramer, Peggy M. Cawthon, Li‐Yung Lui, Theodore M. DeConne et autres

Abstract Systemic inflammation drives sarcopenia and cachexia, which impair the mobility and independence of older adults. We and others have demonstrated that muscle mitochondrial energetics are strongly associated with gait speed, leg power, and mobility limitations. However, the contribution of systemic inflammation …

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New Challenges: Use and Interpretation of Radius Bone Mineral Density

Jane A. Cauley, Li‐Yung Lui, Meryl S. LeBoff, Nelson B. Watts

CONTEXT: It is unknown if isolated low bone mineral density (BMD) "osteoporosis" at the radius is associated with increased fracture risk, not only at the wrist but elsewhere, and whether it reflects more generalized skeletal fragility. OBJECTIVE: This work aimed to review …

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Risk Factors for Bone Microarchitecture Impairments in Older Men With Type 2 Diabetes—The MrOS Study

Malak Faraj, Ann V. Schwartz, Andrew J. Burghardt, Dennis M. Black et autres

CONTEXT: Impaired bone microarchitecture, assessed by high-resolution peripheral quantitative computed tomography (HR-pQCT), may contribute to bone fragility in type 2 diabetes (T2DM) but data on men are lacking. OBJECTIVE: To investigate the association between T2DM and HR-pQCT parameters in older men. METHODS: …

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Epidemiology of fractures in adults of African ancestry with diabetes mellitus: A systematic review and meta-analysis

Tessa Makebeh, Jakub Mesinovic, Kevin Djopseu, Catherine Martin et autres

Diabetes mellitus (DM) is associated with increased fracture risk in White adults. However, the impact of DM on fractures in Black adults is unknown. This systematic review and meta-analysis investigated the association between DM and fractures in adults of African ancestry. MEDLINE, …

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Pre-treatment bone mineral density and the benefit of pharmacologic treatment on fracture risk and BMD change: analysis from the FNIH-ASBMR SABRE project

Marian Schini, Tatiane Vilaça, Li‐Yung Lui, Susan K. Ewing et autres

Some osteoporosis drug trials have suggested that treatment is more effective in those with low BMD measured by DXA. This study used data from a large set of randomized controlled trials (RCTs) to determine whether the anti-fracture efficacy of treatments differs according …

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Role of Cardiorespiratory Fitness and Mitochondrial Oxidative Capacity in Reduced Walk Speed of Older Adults with Diabetes

Sofhia V. Ramos, Giovanna Distéfano, Li‐Yung Lui, Peggy M. Cawthon et autres

Cardiorespiratory fitness and mitochondrial oxidative capacity are associated with reduced walking speed in older adults. The impact of cardiorespiratory fitness and mitochondrial oxidative capacity on walking speed in older adults with diabetes has not been clearly defined. We examined differences in cardiorespiratory …