Junfei Chen

Periplocin targets low density lipoprotein receptor-related protein 4 and protects against osteoarthritis

Jincheng Liu, Qingyang Fu, Chunlin Li, Kun Gao et autres

Osteoarthritis (OA) is recognized as the most common chronic joint disease, characterized primarily by the degeneration of articular cartilage. Through screening a natural product library, we identified periplocin as a candidate agent capable of promoting chondrocyte anabolism. Periplocin, a cardiotonic steroid isolated …

cn (code pays fourni par la source)

Pleuromutilins Suppress Hepatocellular Carcinoma Growth via ABCA1 Inhibition-Induced Cholesterol Accumulation

Mingshan Zhou, Jie Cao, Junfei Chen, Bohan Zhang et autres

Bcakground: Hepatocellular carcinoma (HCC) is a prevalent malignancy with limited therapeutic options. Drug repurposing offers an attractive strategy to accelerate anticancer discovery. The pleuromutilin class of antibiotics, including the human-approved agent lefamulin and the veterinary drug tiamulin, has shown preliminary anticancer potential, …

cn (code pays fourni par la source)

Shouhui Tongbian capsule promotes calcium absorption by regulating gut microbiota and protects against osteoporosis

Mingyu Xu, Qingyang Fu, Jincheng Liu, Junfei Chen et autres

cn (code pays fourni par la source)

KIAA1429-mediated M6A methylation inhibits osteoclast differentiation via stabilizing Lrp4 mRNA and protects against osteoporosis

Jincheng Liu, Qingyang Fu, Mengli Li, Junfei Chen et autres

N 6 -methyladenosine (m 6 A) is a novel epigenetic modification that has been reported to be involved in the progression of osteoporosis (OP), providing new insights into the pathogenesis of OP. The methyltransferases KIAA1429 [also known as virus-like m 6 A …

cn (code pays fourni par la source)

Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer

Peiye Shen, Kaiyan Ye, Huaijiang Xiang, Zhenfeng Zhang et autres

Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer exhibited a unique dependency on the regulatory machinery of transcriptional termination, particularly, cleavage and polyadenylation specificity factor (CPSF) complex. Genetic abrogation …

cn, hk (code pays fourni par la source)

Features of metabolism associated molecular patterns in pancreatic ductal adenocarcinoma

Junfei Chen, Yongjie Wang, Hua Jiang

cn (code pays fourni par la source)

METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism

Yongjie Wang, Junfei Chen, Wei‐Qiang Gao, Yang Ru

N6-methyladenine (m6A) is the most predominant RNA modification, which has been shown to be related to many types of cancers. However, understanding of its role in prostate cancer (PCa) is largely unknown. Here, we report an upregulation of METTL14 that was correlated …

cn (code pays fourni par la source)