Judy A. Westrick

Dataset for microcystin toxin aerosolization from freshwater depends on structure and protonation state

Carlie J. Poworoznek, Grace A. Young, Sharmila I. Thenuwara, Kelli Hummel et autres

HABs that produce MCs are becoming more common and recent research has shown that MC is in the air above the blooms proving to be an inhalation risk. Hundreds of MC congeners have been identified in cHABs with toxicity varying based on …

Structure, Toxicity, Prevalence, and Degradation of Six Understudied Freshwater Cyanopeptides

Blake B. Stringer, Jeremy J. Kodanko, Judy A. Westrick

Anthropogenic influences have increased global warming and eutrophication, escalating the frequency and severity of harmful cyanobacterial blooms (cHABs) in freshwater ecosystems. These blooms release cyanopeptides, a diverse class of bioactive compounds with varying acute and chronic toxicities upon ingestion. To date, research …

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The Great Lakes Winter Grab: Limnological data from a multi‐institutional winter sampling campaign on the Laurentian Great Lakes

Ge Pu, Kirill Shchapov, Nolan J. T. Pearce, Kelly L. Bowen et autres

Abstract Interest in winter limnology is growing rapidly, but progress is hindered by a shortage of standardized multivariate datasets on winter conditions. Addressing the winter data gap will enhance our understanding of winter ecosystem function and of lake response to environmental change. …

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Regional and Longitudinal Dynamics of Cyanobacterial Blooms/Cyanobiome and Cyanotoxin Production in the Great Lakes Area

Faizan Saleem, Jennifer L. Jiang, Enze Li, Kevin Tran et autres

Cyanobacteria (blue-green algae) are a diverse group of prokaryotic microorganisms that impact global biogeochemical cycles. Under eutrophic conditions, cyanobacterial species can produce cyanotoxins, resulting in harmful algal blooms (cHABs) that degrade water quality and result in economic and recreational losses. The Laurentian …

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Intraspecific diversity is critical to population-level risk assessments

René S. Shahmohamadloo, Seth M. Rudman, Catherine I. Clare, Judy A. Westrick et autres

Environmental risk assessment (ERA) is critical for protecting life by predicting population responses to contaminants. However, routine toxicity testing often examines only one genotype from surrogate species, potentially leading to inaccurate risk assessments, as natural populations typically consist of genetically diverse individuals. …

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Exposure of Ldlr−/− Mice to a PFAS Mixture and Outcomes Related to Circulating Lipids, Bile Acid Excretion, and the Intestinal Transporter ASBT

Katherine Roth, Zhao Yang, Manisha Agarwal, Johnna A. Birbeck et autres

BACKGROUND: Previous epidemiological studies have repeatedly found per- and polyfluoroalkyl substances (PFAS) exposure associated with higher circulating cholesterol, one of the greatest risk factors for development of coronary artery disease. The main route of cholesterol catabolism is through its conversion to bile …

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Elemental Composition of Commercially Available Cannabis Rolling Papers

Derek D. Wright, Michelle M. Jarvie, Benjamin Southwell, Carmen Kincaid et autres

With the recent legalization of cannabis in multiple jurisdictions and widespread use as a medical treatment, there has been an increased focus on product safety and the potential impacts of contaminants on human health. One factor that has received little attention is …

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Novel in-source fragments used to identify linear microcystins with C-terminal arginine by UHPLC-ESI-MS/MS

Sharmila I. Thenuwara, Judy A. Westrick, Dragan Isailović

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Loss of flavin-containing monooxygenase 3 modulates dioxin-like polychlorinated biphenyl 126-induced oxidative stress and hepatotoxicity

Manisha Agarwal, Katherine Roth, Zhao Yang, Rahul Sharma et autres

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Identification of Serine-Containing Microcystins by UHPLC-MS/MS Using Thiol and Sulfoxide Derivatizations and Detection of Novel Neutral Losses

Sanduni H. Premathilaka, Judy A. Westrick, Dragan Isailović

Microcystins (MCs) are hepatotoxic cyclic heptapeptides produced by cyanobacteria, and their structural diversity has led to the discovery of more than 300 congeners to date. However, with known amino acid combinations, many more MC congeners are theoretically possible, suggesting many remain unidentified. …

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An assessment of a biosensor system for the quantification of microcystins in freshwater cyanobacterial blooms

Justin D. Chaffin, Katelyn B. Barker, Sarah R. Bickman, John F. Bratton et autres

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Aerosolized Cyanobacterial Harmful Algal Bloom Toxins: Microcystin Congeners Quantified in the Atmosphere

Jia H. Shi, Nicole E. Olson, Johnna A. Birbeck, Jin Pan et autres

Cyanobacterial harmful algal blooms (cHABs) have the potential to adversely affect public health through the production of toxins such as microcystins, which consist of numerous molecularly distinct congeners. Microcystins have been observed in the atmosphere after emission from freshwater lakes, but little …

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