Immunotoxicity and cancer risk exacerbation induced by tris(1,3-dichloro-2-propyl) phosphate exposure: insights from macrophage inflammatory responses and in vivo tumor models
Rattachement africain : sg, cn. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is widely detected in human tissues and associated with significant health risks. However, the immunotoxicity and health risk mechanisms of long-term TDCPP exposure remain poorly understood. This study integrates mRNA sequencing (mRNA-seq) and high-throughput cytokine profiling to elucidate key transcriptional and secretory changes associated with TDCPP-induced inflammatory responses. The findings underscore the potential health implications of TDCPP exposure, elucidating its inflammatory effects at the cellular level and in a breast cancer mouse model. TDCPP exposure led to significant secretion of TNF-α and other cytokines. mRNA-seq and cytokine analysis demonstrated that TDCPP activates the GSDMD/Caspase-8 pathway through TNF signaling, triggering cell death in THP-1 macrophages, resulting in an inflammation response, and aggravating tumor progression. RIPK1 serves as a pivotal regulatory factor in the TNF signaling pathway, playing a central role in modulating both cell death and inflammatory responses. In vivo studies using BALB/c mice showed that TDCPP enhanced cancer cell proliferation and promoted damage to liver and lung tissues. These results highlight the need for a more rigorous evaluation of the environmental and public health impacts of TDCPP and structurally related compounds, as TDCPP exposure may exacerbate health effects, particularly in vulnerable populations with weakened immunity or pre-existing conditions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Immunotoxicity and cancer risk exacerbation induced by tris(1,3-dichloro-2-propyl) phosphate exposure: insights from macrophage inflammatory responses and in vivo tumor models
- Date Crossref
- 01/11/2025
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National University of Singapore pays non établi dans la noticeUniversité ou école supérieure
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National University Cancer Institute pays non établi dans la noticeUniversité ou école supérieure
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Hubei University of Medicine Department of Infection Control pays non établi dans la noticeUniversité ou école supérieure
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Taihe Hospital pays non établi dans la noticeÉtablissement de santé
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Shanghai University pays non établi dans la noticeUniversité ou école supérieure
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Shanghai Municipal Center For Disease Control Prevention pays non établi dans la noticeOrganisme public
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School of Environmental and Chemical Engineering Institute of Environmental Pollution and Health pays non établi dans la noticeUniversité ou école supérieure
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State Environmental Protection Key Laboratory of the Assessment of Effects of Emerging Pollutants on Environmental and Human Health Department of Environmental Health pays non établi dans la noticeStructure de recherche
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Yong Loo Lin School of Medicine Department of Pharmacology pays non établi dans la noticeUniversité ou école supérieure
National University of Singapore, National University Cancer Institute et Department of Infection Control — Hubei University of Medicine, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.