Accès ouvert
2026
article
OpenAlex
Aurélia Joly, Ana-Maria Popmihaylova, Corinne Rancurel, Julie Soltys et autres
Chromatin modulators, like Polycomb group proteins, are key epigenetic regulators of gene expression and are frequently mutated in cancers. In adult stem cells, epigenetic regulation maintains their identity and controls their differentiation during homeostasis or aging, but its direct role in tumorigenesis …
ca, fr
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Deborah Mackay, Alphy John, Christian Christensen, Edward Sander Connolly et autres
In adult tissues, stem cells (SCs) reside in specialized niches, where they remain relatively stationary state until activated by injury. While migration is essential for regeneration, mechanisms guiding SCs towards injury sites remain poorly understood due to challenges in tracking them in …
dk, fr
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Aurélia Joly, Ana-Maria Popmihaylova, Corinne Rancurel, Julie Soltys et autres
Chromatin modulators, like Polycomb group proteins, are key epigenetic regulators of gene expression and are frequently mutated in cancers. In adult stem cells, epigenetic regulation maintains their identity and controls their differentiation during homeostasis or aging, but its direct role in tumorigenesis …
fr, ca
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Stephanie Makdissi, Rihab Loudhaief, Smitha George, Muhammad Salim et autres
Intestinal epithelium regeneration and homeostasis must be tightly regulated. Alteration of epithelial homeostasis is a major contributing factor to diseases such as colorectal cancer and inflammatory bowel diseases. Many pathways involved in epithelial regeneration have been identified, but more regulators remain undiscovered. …
ca
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Donna S. Mackay, Annie T. John, Christian Christensen, Rihab Loudhaief et autres
Abstract In adult tissues, stem cells (SCs) reside in specialized niches, where they are maintained in a quiescent state until activated by injury. Once activated, they migrate towards injured sites, where they proliferate and differentiate to replenish lost or damaged cells. Although …
dk, fr
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Christian Christensen, Quentin Laurichesse, Rihab Loudhaief, Julien Colombani et autres
Rapidly renewable tissues adapt different strategies to cope with environmental insults. While tissue repair is associated with increased intestinal stem cell (ISC) proliferation and accelerated tissue turnover rates, reduced calorie intake triggers a homeostasis-breaking process causing adaptive resizing of the gut. Here …
dk
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Rihab Loudhaief, Rouba Jneid, Christian Christensen, Duncan J. D. Mackay et autres
It is well established that tumor necrosis factor (TNF) plays an instrumental role in orchestrating the metabolic disorders associated with late stages of cancers. However, it is not clear whether TNF/TNF receptor (TNFR) signaling controls energy homeostasis in healthy individuals. Here, we …
dk
(code pays fourni par la source)
Accès ouvert
2023
article
OpenAlex
Rouba Jneid, Rihab Loudhaief, Nathalie Zucchini-Pascal, Marie-Paule Nawrot-Esposito et autres
Bacillus thuringiensis subsp. kurstaki ( Btk ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, Btk and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight …
lb, fr
(code pays fourni par la source)
2023
preprint
OpenAlex
Christian F. Christensen, Quentin Laurichesse, Rihab Loudhaief, Julien Colombani et autres
Abstract Rapidly renewable tissues adapt different strategies to cope with environmental insults. While tissue repair is associated with increased ISC proliferation and accelerated tissue turnover rates, reduced calorie intake triggers a homeostasis-breaking process causing adaptive resizing of the gut. Here we show …
dk
(code pays fourni par la source)
Accès ouvert
2022
peer-review
OpenAlex
Rouba Jneid, Rihab Loudhaief, Nathalie Zucchini-Pascal, Marie-Paule Nawrot-Esposito et autres
Bacillus thuringiensis subsp.kurstaki (Btk) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes.Hence, Btk and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to fight crop pests.However, Btk belongs …
lb, fr
(code pays fourni par la source)
Accès ouvert
2022
preprint
OpenAlex
Rouba Jneid, Rihab Loudhaief, Nathalie Zucchini-Pascal, Marie-Paule Nawrot-Esposito et autres
Abstract Bacillus thuringiensis subsp. kurstaki ( Btk ) is a strong pathogen toward lepidopteran larvae thanks to specific Cry toxins causing leaky gut phenotypes. Hence, Btk and its toxins are used worldwide as microbial insecticide and in genetically modified crops, respectively, to …
fr, lb
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Valentina Palmerini, Silvia Monzani, Quentin Laurichesse, Rihab Loudhaief et autres
The Drosophila tumour necrosis factor (TNF) ligand-receptor system consists of a unique ligand, Eiger (Egr), and two receptors, Grindelwald (Grnd) and Wengen (Wgn), and therefore provides a simple system for exploring the interplay between ligand and receptors, and the requirement for Grnd …
it, dk, ch
(code pays fourni par la source)