Zhe Wu

A Weekly Symptom Questionnaire as a Proxy for Symptom Diaries in Acute Exacerbations of Fibrotic Interstitial Lung Disease

Leda Yazbeck, Zhe Wu, David J. F. Smith, Chloë I. Bloom et autres

Acute exacerbations in patients with interstitial lung disease (AE-ILD) are characterised by diffuse alveolar damage and are associated with significant morbidity and mortality. Previous AE-ILD studies have been retrospective in nature. To address this gap, we established a prospective cohort of patients …

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Case Report: A novel KRT74 variant in an eight-year-old boy with alopecia totalis successfully treated with baricitinib

Yidong Tan, Jinxiang Yang, Xuanyi Chen, Zhe Wu et autres

Alopecia areata is an autoimmune condition characterized by non-scarring hair loss, with genetic factors playing a significant role in disease susceptibility. We report the case of an 8-year-old boy with alopecia totalis harboring a heterozygous KRT74 variant. While his mother and brother …

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A comparison of respiratory oscillometry and spirometry in idiopathic pulmonary fibrosis: performance time, symptom burden and test–retest reliability

Suhani Patel, Karl Peter Sylvester, Zhe Wu, Serena Rhamie et autres

Study question: In large multinational patient surveys, spirometry (which requires repeated, reproducible maximal efforts) can be associated with cough, breathlessness and tiredness, particularly in those with idiopathic pulmonary fibrosis (IPF). Oscillometry is an effort-independent test of airways resistance and reactance. We hypothesised …

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Cough Severity Visual Analog Scale Assesses Cough Burden and Predicts Survival in Idiopathic Pulmonary Fibrosis

Zhe Wu, David J. F. Smith, Leda Yazbeck, Peter Timothy Saunders et autres

Background Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease, with most patients reporting cough. Currently, there are no proven treatments. We examined the use of low dose controlled-release morphine compared with placebo as an antitussive therapy in individuals with idiopathic pulmonary …

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Morphine for treatment of cough in idiopathic pulmonary fibrosis (PACIFY COUGH): a prospective, multicentre, randomised, double-blind, placebo-controlled, two-way crossover trial

Zhe Wu, Lisa G. Spencer, WINSTON A. S. BANYA, John Westoby et autres

BACKGROUND: Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease, with most patients reporting cough. Currently, there are no proven treatments. We examined the use of low dose controlled-release morphine compared with placebo as an antitussive therapy in individuals with idiopathic pulmonary …

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Treatment of obstructive sleep apnoea in patients with interstitial lung disease improves quality of life and survival

Katherine Jane Myall, Alex West, Jennifer Martinovic, Zhe Wu et autres

Introduction: Obstructive sleep apnoea (OSA) is common in patients with progressive fibrotic interstitial lung disease (PFILD), impacting quality of life and survival. There is a paucity of evidence to support use of continuous positive airway pressure (CPAP). We aimed to assess the …

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Late Breaking Abstract - Morphine sulfate for the treatment of cough in Idiopathic Pulmonary Fibrosis The PAciFy Cough Randomized Clinical Trial

Zhe Wu, Lisa G. Spencer, WINSTON A. S. BANYA, Nazia Chaudhuri et autres

Background: The majority of patients with idiopathic pulmonary fibrosis (IPF) report cough and it is associated with significant negative physical, social and psychological consequences. Objective: We examined the use of low dose controlled-release morphine sulfate (MST) as an antitussive therapy. Methods: PulmonAry …

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Late Breaking Abstract - Characterising cough in hypersensitivity pneumonitis

Zhe Wu, David J. F. Smith, Leda Yazbeck, Toby M. Maher et autres

Background: While an often clinically reported symptom in hypersensitivity pneumonitis (HP), the burden of cough has yet to be elucidated. Objective: Examine objective and subjective cough measures in patients with chronic HP, factors associated with cough, and response to treatment. Methods: We …

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Combination of BAL and Computed Tomography Differentiates Progressive and Non-progressive Fibrotic Lung Diseases

Joseph Luke Barnett, Toby M. Maher, Jennifer Kathleen Quint, Alexander Adamson et autres

Abstract Rationale Identifying patients with pulmonary fibrosis (PF) at risk of progression can guide management. Objectives To explore the utility of combining baseline BAL and computed tomography (CT) in differentiating progressive and nonprogressive PF. Methods The derivation cohort consisted of incident cases …

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Nocturnal Hypoxemia Associates With Symptom Progression and Mortality in Patients With Progressive Fibrotic Interstitial Lung Disease

Katherine Jane Myall, Alex West, Jennifer L. Martinovic, Jodie L. Lam et autres

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The Burden and Impact of Cough in Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the Prospective Observational PROFILE Study

Peter Timothy Saunders, Zhe Wu, William A. Fahy, Iain D. Stewart et autres

Abstract Rationale Cough is a commonly reported symptom in idiopathic pulmonary fibrosis (IPF) that negatively impacts patient-reported quality of life (QoL). However, both the burden of cough at diagnosis and the behavior of cough over time have not been systematically described in …

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Rituximab versus intravenous cyclophosphamide in patients with connective tissue disease-associated interstitial lung disease in the UK (RECITAL): a double-blind, double-dummy, randomised, controlled, phase 2b trial

Toby M. Maher, Veronica A Tudor, Peter Timothy Saunders, Michael Gibbons et autres

Background Rituximab is often used as rescue therapy in interstitial lung disease (ILD) associated with connective tissue disease (CTD), but has not been studied in clinical trials. This study aimed to assess whether rituximab is superior to cyclophosphamide as a treatment for …

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