Yingcong Chen

The glycolytic enzyme PGAM1 functions as a metabolic–autophagy checkpoint to coordinate growth and stress tolerance

Yi Zhang, Pengwei Zhao, Hangfei Liang, Zhaojie Liu et autres

cn (code pays fourni par la source)

A Breast Vision Pathology Foundation Model for Real-world Clinical Utility

Yingxue Xu, Zhengyu Zhang, Xiuming Zhang, Mengwei Xu et autres

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment serves as the gold standard for diagnosis and guides treatment planning, surgical …

A Breast Vision Pathology Foundation Model for Real-world Clinical Utility

Yingxue Xu, Zhengyu Zhang, Xiuming Zhang, Mengwei Xu et autres

Pathology foundation models have shown strong retrospective performance, but whether such systems can support clinically relevant use remains unclear. This challenge is particularly important in breast cancer, where pathological assessment serves as the gold standard for diagnosis and guides treatment planning, surgical …

Establishment of a yeast essential protein conditional-degradation library and screening for autophagy-regulating genes

Yi Zhang, Yingcong Chen, Choufei Wu, Zhengyi Cai et autres

Macroautophagy/autophagy is an evolutionarily conserved intracellular degradation pathway that relies on vacuoles or lysosomes. Over 40 ATG genes have been identified in yeast cells as participants in various types of autophagy, although these genes are non-essential. While some essential genes involved in …

cn (code pays fourni par la source)

Phenylboronic Acid-Functionalized Au Nanostructured Film for Ultrasensitive Detection of cis -Hydroxy Inorganic Arsenate in Environmental and Biological Samples

Jiliang Yan, Chunyan You, Xiaodan Chen, Danting Yang et autres

Arsenic is considered one of the major threats to human health, and development of chemical sensors for rapid and simple arsenic detection is increasing attention. In this paper, we developed a chemical sensing platform targeting arsenic oxide (As(V)) based on phenylboronic acid’s …

cn (code pays fourni par la source)

Two distinct regulatory pathways govern Cct2-Atg8 binding in the process of solid aggrephagy

Yuting Chen, Zhaojie Liu, Yi Zhang, Miao Ye et autres

CCT2 serves as an aggrephagy receptor that plays a crucial role in the clearance of solid aggregates, yet the underlying molecular mechanisms by which CCT2 regulates solid aggrephagy are not fully understood. Here we report that the binding of Cct2 to Atg8 …

cn (code pays fourni par la source)

Ca2+-triggered Atg11–Bmh1/2–Snf1 complex assembly initiates autophagy upon glucose starvation

Weijing Yao, Yingcong Chen, Yi Zhang, Shu Zhong et autres

Autophagy is essential for maintaining glucose homeostasis. However, the mechanism by which cells sense and respond to glucose starvation to induce autophagy remains incomplete. Here, we show that calcium serves as a fundamental triggering signal that connects environmental sensing to the formation …

cn (code pays fourni par la source)

Energy deprivation-induced autophagy and aggrephagy: insights from yeast and mammals

Siyu Fan, Yingcong Chen, Weijing Yao, Cong Yi

Autophagy plays a crucial role in maintaining cellular homeostasis in response to various stimuli. Compared to research on nutrient deprivation-induced autophagy, the understanding of the molecular mechanisms and physiological/pathological significance of autophagy triggered by energy deprivation remains limited. A primary focus of …

cn (code pays fourni par la source)

TOR‐mediated Ypt1 phosphorylation regulates autophagy initiation complex assembly

Weijing Yao, Yuting Chen, Yingcong Chen, Pengwei Zhao et autres

cn (code pays fourni par la source)

ReTR: Modeling Rendering Via Transformer for Generalizable Neural Surface Reconstruction

Yixun Liang, Hao He, Yingcong Chen

Mec1 regulates PAS recruitment of Atg13 via direct binding with Atg13 during glucose starvation-induced autophagy

Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen et autres

Mec1 is a DNA damage sensor, which performs an essential role in the DNA damage response pathway and glucose starvation-induced autophagy. However, the functions of Mec1 in autophagy remain unclear. In response to glucose starvation, Mec1 forms puncta, which are recruited to …

cn (code pays fourni par la source)

Atg1-mediated Atg11 phosphorylation is required for selective autophagy by regulating its association with receptor proteins

Weijing Yao, Yixing Li, Yingcong Chen, Yuting Chen et autres

Atg11 is an adaptor protein required for the induction of selective autophagy via receptor binding. However, our understanding of the molecular mechanisms by which it regulates selective autophagy remains incomplete. Here, we show that Atg11 is phosphorylated by Atg1. Rapamycin treatment or …

cn (code pays fourni par la source)