Maria Lucia Richter

Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8+ T cell differentiation

Doğuş Altunöz, Ramin Shakiba, Kaushikk Ravi Rengarajan, Hamsa Narasimhan et autres

Abstract Maintaining a balanced immunity between pathogen defense and tolerance to environmental antigens in neonates is essential for survival and the establishment of life-long immune homeostasis. Instructed by environmental signals, type 1 conventional dendritic cells (cDC1) contribute to both processes but how …

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Peri-weaning, diet-induced activation of an IFNγ-mediated regulatory circuit promotes cDC1 maturation and CD8+ T cell differentiation.

Doğuş Altunöz, Ramin Shakiba, Kaushikk Ravi Rengarajan, Hamsa Narasimhan et autres

Maintaining a balanced immunity between pathogen defense and tolerance to environmental antigens in neonates is essential for survival and the establishment of life-long immune homeostasis. Instructed by environmental signals, type 1 conventional dendritic cells (cDC1) contribute to both processes but how the …

at (code pays fourni par la source)

Antagonizing niche signals regulate the emergence of postnatal neural stem cells and allow enlargement of their pool

Daniela Cimino, Anna Danese, Annina Denoth‐Lippuner, Paulina Chlebik et autres

Abstract Adult neural stem cells (aNSCs) of the lateral ventricular sub-ventricular zone (V-SVZ) are set aside during embryogenesis from a pool of slowly dividing neural stem/progenitor cells (NSPCs) residing in the lateral ganglionic eminence (LGE). The time of aNSCs specification coincides with …

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Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance

Yiling Li, Anthi C. Krontira, Franziska Vierl, Maria Lucia Richter et autres

Stem cells balance self-renewal with differentiation. Priming, i.e., low-level expression of differentiation-related genes, enables stem cells to remain undifferentiated and progeny to fast proceed in up-regulation of differentiation genes. Here, we investigated transcriptional priming during neurogenesis to search for key regulators. Assay …

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Comprehensive single cell profiling of ageing glial cells reveals impaired Wnt signalling and Jun transcription factors regulating cortical astrocytes

Maroussia Hennes, Manja Thorwirth, Chu Lan Lao, Jeffrey A. Stogsdill et autres

Abstract Understanding age-related cellular dysfunction in the brain is essential for developing strategies to promote healthy ageing. Towards this aim, we took advantage of a previously established mild dissociation method to profile cells in the cerebral cortex grey matter of adult and …

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Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3

Cedric Bressan, Archana Gengatharan, Raquel Rodríguez-Aller, Maria Lucia Richter et autres

Summary In many tissues stem cells are located lining a fluid-filled volume and their neighboring niche cells include cells with beating cilia. However, the role of mechanical forces created by cilia beating on stem cells remains elusive. We developed an approach to …

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Physiological ageing impairs Wnt signalling in cortical astrocytes

Maria Lucia Richter

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A microtubule–chromatin axis controls neural stem cell fate and neurodevelopmental disease

Maria Lucia Richter, Florencia Merino, Magdalena Götz

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Overcoming the hurdle of myelin deficiency in transplanted neurons after brain injury

Maria Lucia Richter, Maria Fernanda Martinez Reza

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Benchmarking scRNA-seq copy number variation callers

Katharina Schmid, Aikaterini Symeonidi, Dmytro Hlushchenko, Maria Lucia Richter et autres

Copy number variations (CNVs), the gain or loss of genomic regions, are associated with disease, especially cancer. Single cell technologies offer new possibilities to capture within-sample heterogeneity of CNVs and identify subclones relevant for tumor progression and treatment outcome. Several computational tools …

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Astrocyte diversity and subtypes: aligning transcriptomics with multimodal perspectives

Maroussia Hennes, Maria Lucia Richter, Judith Fischer, Magdalena Götz

Astrocytes are considered a diverse cell population, carrying out many functions essential for supporting neuronal activity. The surge of sc/snRNA-sequencing data greatly expands our understanding of heterogeneous astrocyte gene expression, but also leads to confusion about the multitude of described astrocyte subtypes …

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Fibrin-containing Hydrogels Regulate Human Astrocyte State and Neuronal Reprogramming

Maria Lucia Richter, Giacomo Masserdotti, Thomas Distler

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