Accès ouvert
2026
dataset
OpenAlex
Nicole Endresz, Maria Eleni Fafouti, Keon Arbabi, Xiaolin Zhou et autres
This dataset contains processed data supporting the manuscript “Selective depletion of upper-layer somatostatin interneuron subtypes in schizophrenia”. It includes re-annotated cell-level metadata from seven single-nucleus RNA-sequencing (snRNA-seq) datasets and one spatial transcriptomic (Xenium) dataset. Cell subclass-level differential expression results are provided for …
us, ca
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Nicole Endresz, Maria Eleni Fafouti, Keon Arbabi, Xiaolin Zhou et autres
This dataset contains processed data supporting the manuscript “Selective depletion of upper-layer somatostatin interneuron subtypes in schizophrenia”. It includes re-annotated cell-level metadata from seven single-nucleus RNA-sequencing (snRNA-seq) datasets and one spatial transcriptomic (Xenium) dataset. Cell subclass-level differential expression results are provided for …
us, ca
(code pays fourni par la source)
Accès ouvert
2026
dataset
OpenAlex
Nicole Endresz, Maria Eleni Fafouti, Keon Arbabi, Xiaolin Zhou et autres
This dataset contains processed data supporting the manuscript “Selective depletion of upper-layer somatostatin interneuron subtypes in schizophrenia”. It includes re-annotated cell-level metadata from seven single-nucleus RNA-sequencing (snRNA-seq) datasets and one spatial transcriptomic (Xenium) dataset. Cell subclass-level differential expression results are provided for …
us, ca
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Georgina A. Craig, Emeric Merour, Luise A. Seeker, Annette J. Haughian et autres
Cognitive decline in aging impacts quality of life, for which therapeutic interventions are lacking. Why some individuals experience more severe cognitive decline with aging is unclear. Here we uncover a role for the brain's myelin-forming cells-oligodendrocytes-in explaining this variance. By investigating neuropathological …
ca, gb, us, ie
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Katherine M Rynard, Elizabeth Radley, Ai Tian, Maahil Arshad et autres
Abstract RNA splicing shapes neuronal identity and disease risk, yet current maps lack the developmental resolution and depth to resolve this complexity. Here, we integrate deep long-read RNA sequencing and proteomics in iPSC-derived cortical neurons to generate a high-resolution proteogenomic atlas of …
ca, gb, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Dibyadeep Datta, Amy F.T. Arnsten, Stacey J. Sukoff Rizzo, Afonso C. Silva et autres
Schizophrenia, major depressive disorder (MDD), and Alzheimer's disease (AD) involve dysfunction of distributed cortical-subcortical networks that support complex cognitive processes and emotion regulation. Convergent evidence identifies the dorsolateral prefrontal cortex (dlPFC) as a critical site of molecular, cellular, and circuitry alterations in …
us, ca, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
M. Feyerabend, S. Pommer, Samuel A. Mestern, M. S. Jimenez-Sosa et autres
In primates, primary visual cortex (V1) circuits support early visual processing, whereas in the lateral prefrontal cortex (LPFC), they support higher-order computations. Here, we characterized the intrinsic electrophysiological (e)-properties and morphology of excitatory (EXC), fast-spiking inhibitory (FSI), and non-fast-spiking inhibitory (NFSI) neurons …
ca, de, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Ricardo Harripaul, Ansa Rabia, Nasim Vasli, Anna Mikhailov et autres
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 1 in 54 children worldwide, imposing enormous economic and socioemotional burden on families and communities. Genetic studies of ASD have identified de novo copy number variants (CNVs) and point mutations …
ca, pk, ir, Maroc, us, sa, bd, gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Carme Uribe, Lucas Narciso, Sang Soo Cho, Maia Zilberman et autres
PURPOSE: The suitability of the white matter centrum semiovale (CS) as a pseudo-reference region for simplified reference tissue model 2 (SRTM2) with [¹⁸F]SynVesT-1 PET has not been evaluated in youth cohorts. We aimed to assess noninvasive quantification methods and determine the minimum …
ca, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Jannis Körner, Derek Howard, Hans Jürgen Solinski, Marisol Mancilla Moreno et autres
Human dermal sleeping nociceptors display ongoing activity in neuropathic pain, affecting 10% of the population. Despite advances in rodents, a molecular marker for these mechano-insensitive C-fibers (CMis) in human skin remains elusive, preventing targeted therapy. Using a Patch-seq approach, we combined single-cell …
de, ca, us, gb
(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Keon Arbabi, Shahrzad Ghazisaeidi, Minjin Kim, Bharti Kukreja et autres
Abstract Pregnancy is a critical window for neuroplasticity and maternal mental health, yet our understanding of the molecular and cellular changes underlying this adaptation remains incomplete. Here we profile the female mouse brain in nulliparous, late-pregnant and postpartum states with three single-cell …
ca, us
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Fernanda C. Dos Santos, Xiaolin Zhou, Kevan P. Clifford, Alex Gonzalez Segura et autres
Postmortem studies suggest that somatostatin-expressing (SST+) neurons are selectively vulnerable in aging and depression. We developed a novel polygenic risk score (PRS) as an in-vivo index of inter-individual variability of SST-related function and evaluated its association with late-life depression (LLD)-related phenotypes. We …
ca, es, us
(code pays fourni par la source)