A Novel Polygenic Risk Score Indexing Somatostatin-Expressing Inhibitory Neurons Predicts Somatostatin-Expressing Cell Proportions and Severity of Symptoms in Late-Life Depression
Fernanda C. Dos Santos, Xiaolin Zhou, Kevan P. Clifford, Alex Gonzalez Segura et autres
Postmortem studies suggest that somatostatin-expressing (SST+) neurons are selectively vulnerable in aging and depression. We developed a novel polygenic risk score (PRS) as an in-vivo index of inter-individual variability of SST-related function and evaluated its association with late-life depression (LLD)-related phenotypes. We …
ca, es, us (code pays fourni par la source)
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Biological Psychiatry Global Open Science