Jeffrey B. Schwimmer

Response to Vibration‐controlled transient elastography in pediatric metabolic dysfunction‐associated steatotic liver disease: Considerations for risk stratification and clinical use

Lauren B. Nichols, Simon Oakes, Cynthia A. Behling, Jean Pappas Molleston et autres

The authors declare no conflict of interest. Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Clinical and Metabolomic Panel for Noninvasive Screening of Biopsy-Confirmed MASH in Children and Adolescents

Helaina E. Huneault, Shrramana Ganesh Sudhakar, A. Gent, Zachery Ryan Jarrell et autres

BACKGROUND & AIMS: Noninvasive tests to identify pediatric metabolic dysfunction-associated steatohepatitis (MASH) remain a critical need. We aimed to develop and validate a screening panel that identifies biopsy-confirmed MASH in children and adolescents using clinical and metabolomics data. METHODS: Fasting serum from …

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Beyond Metabolically Healthy Obesity

Nidhi P. Goyal, Jeffrey B. Schwimmer

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Associations Between Adverse Childhood Experiences and Disordered Eating in US Youth: The PLATE Study

Sierra L Martin, Leah M. Parsons, Christin M. Ogle, Jackie Shiels et autres

Objective: To examine associations between individual adverse childhood experiences (ACEs) and disordered eating behaviors (DEBs) in US youth. In addition, to test mediation and moderation by psychosocial and contextual factors. Method: The study was based on a cross-sectional analysis of 47,617 children …

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Adverse childhood experiences and gastrointestinal symptoms in US youth: Psychosocial pathways and protective contexts

Sierra L Martin, Jamie M. Klapp, Jacqueline Shiels, Christin M. Ogle et autres

OBJECTIVE: Although adverse childhood experiences (ACEs) have been linked to gastrointestinal (GI) conditions in children, it remains unclear which specific adversities confer greatest risk and how psychosocial or contextual factors modify these associations. This study identified ACEs most strongly associated with GI …

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Reply: The PNPLA3 paradox—Does genotype modify the clinical utility of the MASLD framework in children?

Tin Bo Nicholas Lam, Nidhi P. Goyal, Kimberly P. Newton, Jeffrey B. Schwimmer

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Vibration‐controlled transient elastography in pediatric metabolic dysfunction‐associated steatotic liver disease

Lauren B. Nichols, Simon Oakes, Cynthia A. Behling, Katherine A. Adams et autres

OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent disease in children. Vibration-controlled transient elastography (VCTE) offers a noninvasive alternative to liver biopsy, using controlled attenuation parameter (CAP) to estimate steatosis and liver stiffness measurement (LSM) for fibrosis. However, pediatric data …

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Longitudinal Analysis of Liver Chemistry Trajectories and Risk of Type 2 Diabetes in Children With Metabolic Dysfunction–Associated Steatotic Liver Disease: A Multicenter Cohort Study

Nhat Quang N. Thai, Lauren F. Chun, Kimberly P. Newton, Laura Wilson et autres

OBJECTIVE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in children and is linked to type 2 diabetes. This study evaluates whether longitudinal changes in liver chemistries-γ-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)-can serve …

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Longitudinal Analysis of Liver Chemistry Trajectories and Risk of Type 2 Diabetes in Children with Metabolic Dysfunction–Associated Steatotic Liver Disease: A Multi-Center Cohort Study

Nhat Quang N. Thai, Lauren F. Chun, Kimberly P. Newton, Laura Wilson et autres

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in children and is linked to type 2 diabetes. This study evaluates whether longitudinal changes in liver chemistries—gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)—can serve …

Longitudinal Analysis of Liver Chemistry Trajectories and Risk of Type 2 Diabetes in Children with Metabolic Dysfunction–Associated Steatotic Liver Disease: A Multi-Center Cohort Study

Nhat Quang N. Thai, Lauren F. Chun, Kimberly P. Newton, Laura Wilson et autres

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease in children and is linked to type 2 diabetes. This study evaluates whether longitudinal changes in liver chemistries—gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)—can serve …

Neighborhood disparities and metabolic dysfunction–associated steatotic liver disease in children with overweight or obesity

Ananya Venkatesh, Nhat Quang N. Thai, Patricia Ugalde‐Nicalo, Martha Ruth Smith et autres

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common pediatric liver disease, yet known biological risk factors do not fully explain its development. This study evaluated the association between social determinants of health (SDH)-including income, education, housing, and environmental factors-and …

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Reclassifying pediatric NAFLD using the steatotic liver disease framework: A multicenter retrospective study from the NASH CRN

Katherine P. Yates, Kimberly P. Newton, Jean Pappas Molleston, Stavra A. Xanthakos et autres

BACKGROUND AND AIMS: The terminology for hepatic steatosis and NAFLD was revised under the umbrella of steatotic liver disease, with metabolic dysfunction-associated steatotic liver disease (MASLD) as the primary subtype. MASLD is defined by hepatic steatosis plus at least 1 cardiometabolic risk …

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