Neighborhood disparities and metabolic dysfunction–associated steatotic liver disease in children with overweight or obesity
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common pediatric liver disease, yet known biological risk factors do not fully explain its development. This study evaluated the association between social determinants of health (SDH)-including income, education, housing, and environmental factors-and MASLD in children with overweight or obesity. METHODS: This cross-sectional study included children with overweight or obesity evaluated in pediatric gastroenterology clinics, stratified by the presence of MASLD. Participants' residential census tracts were linked to the California Healthy Places Index (HPI), where higher scores indicate greater socioeconomic advantage. Generalized linear regression models, adjusted for age, sex, race, ethnicity, and body mass index (BMI), assessed associations between SDH and MASLD. RESULTS: The study included 888 children (mean age: 12.8±2.9 y, mean BMI: 30.6±6.4 kg/m2). Children with MASLD lived in neighborhoods with significantly lower HPI scores than those without MASLD (-0.22 vs. -0.03; 41st vs. 49th percentile, p=0.01). They also resided in areas with significantly lower socioeconomic advantage across multiple HPI subdomains, including housing (-0.16 vs. 0.03; 44th vs. 51st percentile, p<0.001) and economic (-0.38 vs. -0.12; 36th vs. 55th percentile, p<0.001) scores. CONCLUSIONS: Children with MASLD were more likely to live in neighborhoods with greater socioeconomic and environmental disadvantage than their peers with overweight or obesity but without MASLD. These findings highlight potential SDH targets for public health interventions aimed at reducing MASLD risk in children.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neighborhood disparities and metabolic dysfunction–associated steatotic liver disease in children with overweight or obesity
- Date Crossref
- 20/11/2025
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of California San Diego Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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San Diego State University pays non établi dans la noticeUniversité ou école supérieure
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Human Longevity (United States) pays non établi dans la noticeEntreprise
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Rady Children's Hospital-San Diego Department of Gastroenterology pays non établi dans la noticeÉtablissement de santé
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Rosalind Franklin University of Medicine and Science Chicago Medical School pays non établi dans la noticeUniversité ou école supérieure
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Herbert Wertheim School of Public Health and Human Longevity Science pays non établi dans la noticeUniversité ou école supérieure
Department of Pediatrics — University of California San Diego, San Diego State University et Human Longevity (United States), avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.