Charles Chuah

Prolonged BCR::ABL1 induction in the SCL-tTA mouse recapitulates gene expression signatures and therapeutic vulnerabilities of primary imatinib-resistant chronic myeloid leukaemia

Pavithra Shyamsunder, Kian Leong Lee, Zhu En Chan, Charles Chuah et autres

sg, us (code pays fourni par la source)

Kindlin-3 sustains cytokine interleukin-2 signaling by linking its receptor to integrin LFA-1

Zheng-Kai Teng, Neeru Arya, Yinghui Li, Charles Chuah et autres

sg (code pays fourni par la source)

ASC4OPT: asciminib treatment optimization study in patients with chronic myeloid leukemia in chronic phase previously treated with two or more tyrosine kinase inhibitors

Andreas Hochhaus, Philipp le Coutre, Dragana Milojković, Dennis Dong Hwan Kim et autres

de, gb, ca, my, ar, fr, pl, vn, es, it, sg, ch, in, br (code pays fourni par la source)

Somatic mutations at diagnosis in patients with chronic Phase CML receiving frontline imatinib are associated with a higher rate of treatment failure: First analysis from the international CML foundation (iCMLf) genomics alliance on the harmony platform

Susan Branford, Ali Albeer, Ángela Villaverde Ramiro, Joe McConnell et autres

au, nl, es, de, cz, qa, tw, kw, it, ca, us, sg, pl, gb (code pays fourni par la source)

A single-cell atlas of diagnostic bone marrow to uncover the origins of CML relapse following therapy cessation

Vaidehi Krishnan, Xi Ren, Kian Leong Lee, Radhika Sonthalia et autres

us, sg, au, jp (code pays fourni par la source)

Single-cell chromatin profiling reveals early epigenetic reprogramming, subtype-specific regulatory networks, and JAK/STAT–IRF vulnerabilities in high-risk chronic myeloid leukemia

S. Tiong Ong, Pavithra Shyamsunder, BeiJun Chen, Zahid Nawaz et autres

us, sg (code pays fourni par la source)

ASC4OPT 96-week results: Asciminib once or twice daily continues to be highly efficacious and demonstrates favorable safety in patients with chronic myeloid leukemia and suboptimal response, resistance or intolerance to two or more tyrosine kinase inhibitors

Massimo Breccia, Andreas Hochhaus, Philipp le Coutre, Dragana Milojković et autres

it, de, gb, ca, my, ar, cz, fr, pl, vn, es, ch, in, br, sg (code pays fourni par la source)

POSTER: CML-641 Efficacy, Safety, and End-of-Treatment Mutational Results in Patients With Chronic-Phase Chronic Myeloid Leukemia (CP-CML): 5-Year Follow-Up of the Phase 2 OPTIC Study

Jorge Alberto Cortés, Michael Deininger, Jane F. Apperley, Christopher Arthur et autres

CML-641: Efficacy, Safety, and End-of-Treatment Mutational Results in Patients With Chronic-Phase Chronic Myeloid Leukemia (CP-CML): 5-Year Follow-Up of the Phase 2 OPTIC Study

Jorge Alberto Cortés, Michael Deininger, Jane F. Apperley, Christopher Arthur et autres

Deceased donor kidney transplantation in candidates with pre-transplant hematological malignancies: a literature review and recipient allocation proposal in Singapore

Emmett Tsz Yeung Wong, Ian Tatt Liew, Hein Than, Aloysius Ho et autres

sg (code pays fourni par la source)

Superoxide-mediated phosphorylation and stabilization of Mcl-1 by AKT underlie venetoclax resistance in hematologic malignancies

Stephen Jun Fei Chong, Jolin Xiao Hui Lai, Kartini Iskandar, Chuqi Wang et autres

sg, us, fr (code pays fourni par la source)

Mitochondrial DNA Mutations Determine Favourable Molecular Responses to Targeted Kinase Inhibitor Therapy and Impair Oxidative Phosphorylation

Ilaria S. Pagani, Vaidehi Krishnan, John F. Ouyang, Chung Hoow Kok et autres

au, us, sg, gb (code pays fourni par la source)