Hugh Leonard

How to foster new treatment development in ultra-rare tumours? Joint EMA-EORTC multi-stakeholder workshops on ultra-rare sarcomas as a model for rare cancers

Silvia Stacchiotti, Pan Pantziarka, Hugh Leonard, Caroline Voltz et autres

it, be, gb, nl, de, us, fr, es, pl, dk, is (code pays fourni par la source)

Thermomagnetic Bioconvection Flow in a Semitrapezoidal Enclosure Filled With a Porous Medium Containing Oxytactic Micro-Organisms: Modeling Hybrid Magnetic Biofuel Cells

K. Venkatadri, R. Rajeswari, O. Anwar Bég, V. Ramachandra Prasad et autres

Abstract Hybrid fuel cells are becoming increasingly popular in 21st century energy systems engineering. These systems combine multiple features including various geometries, electromagnetic fluids, bacteria (micro-organisms), thermosolutal convection, and porous media. Motivated by these developments in the present work, we simulate the …

in, gb (code pays fourni par la source)

Data from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

AbstractPurpose: Epithelioid hemangioendothelioma (EHE), an ultra-rare sarcoma, poses therapeutic challenges because of limited efficacy of conventional chemotherapy in advanced cases, necessitating exploration of new treatment avenues and identification of novel aggressive biomarkers. This study aimed at (i) utilizing a patient-derived xenograft model …

Figure 3 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Sirolimus inhibited the growth of patient-derived models of EHE. A, Cell growth inhibition curves obtained after exposure to different doses of doxorubicin or sirolimus. Data are reported as the percentage of drug-treated cells compared with control cells and represent mean ± SD …

Supplementary Figure 4 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Supplementary Figure 4. Transcriptomic profiles of EHE clinical tumor and PDX.

Figure 1 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Characterization of EHE PDX and paired cell line. Representative pictures of the EHE clinical sample and corresponding EHE PDX model. A, The histology was assessed on hematoxylin and eosin–stained slides. Scale bar, 100 µm. WWTR1::CAMTA1 dual-color dual-fusion FISH pattern in diploid tumor …

Supplementary Figure 10 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Supplementary Figure 10. GDF-15 down-regulation induced by sirolimus and/or ATF4/5 silencing.

Supplementary Figure 3 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Supplementary Figure 3. Chromosomal architecture of the PDX compared to the clinical sample in chromosomes 7 and 11.

Figure 5 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Circulating GDF-15 levels correlated with disease aggressiveness in patients with EHE. A, Analysis of circulating cytokines in plasma samples of 16 patients with EHE and four healthy donors using the Human XL Cytokine Array showed higher GDF-15 levels in patients compared with …

Figure 2 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

GDF-15 was released by tumor cells in patient-derived models of EHE. A, Assessment of released cytokines in the culture medium of EHE cells using the Human XL Cytokine Array. Detection of GDF-15 by ELISA in culture medium of EHE cell lines and …

Figure 4 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Sirolimus downmodulated GDF-15 release in patient-derived models of EHE through the inhibition of ATF4 and ATF5. A, GDF-15 released in culture medium of control cells and cells exposed for 3 days to doxorubicin or different sirolimus concentrations as detected by ELISA. Data …

Supplementary Figure 1 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Silvia Stacchiotti, Silvia Martini, Sandro Pasquali, Anna Maria Frezza et autres

Supplementary Figure 1. Representative growth curves of the EHE PDX at different passages in mice.