Figure 1 from GDF-15 Predicts Epithelioid Hemangioendothelioma Aggressiveness and Is Downregulated by Sirolimus through ATF4/ATF5 Suppression

Le résumé fourni par la source

Characterization of EHE PDX and paired cell line. Representative pictures of the EHE clinical sample and corresponding EHE PDX model. A, The histology was assessed on hematoxylin and eosin–stained slides. Scale bar, 100 µm. WWTR1::CAMTA1 dual-color dual-fusion FISH pattern in diploid tumor cells showing one single fusion, consistently with the genomic profile. B, Genomic profile of EHE clinical tumor (left) and PDX (right). C, Loss (blue) and gain (red) were depicted in the top. LOH (green) was reported in the bottom (scale bar, 10 µm). D, Scatter plot of significant correlation between the transcriptome of the clinical tumor and the paired PDX (Spearman correlation, rs = 0.916; P < 0.001). E, Morphology of the EHE cell line derived from the PDX growing as monolayer (left, scale bar, 250 µm) and confirmation of WWTR1::CAMTA1 translocation at FISH analysis (right, scale bar, 10 µm). H&E, hematoxylin and eosin; LOH, loss of heterozygosity; RNA-seq, RNA sequencing.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.