Paolo Fraticelli

Insights from comparison of serum IgG4 between T2-eosinophilic asthma and eosinophilic granulomatosis with polyangiitis/idiopathic hypereosinophilic syndrome

Mario Andrea Piga, Matteo Martini, Paolo Fraticelli, Maria Stella Garritani et autres

OBJECTIVES: Eosinophilic granulomatosis with polyangiitis (EGPA) and idiopathic hypereosinophilic syndrome (iHES) are systemic hypereosinophilic diseases largely overlapping. Type 2 (T2)-eosinophilic asthma is documented in 100% and 44-95% of EGPA and iHES patients, respectively, probably representing the beginning of the systemic eosinophilic disorders, …

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ANCA-negative EGPA: only eosinophils without vasculitis? Insights from anti-T2 biologics

Mario Andrea Piga, Paolo Fraticelli, Leonardo Antonicelli, Maria Stella Garritani et autres

The pathogenic role of p-ANCA in eosinophilic granulomatosis with polyangiitis (EGPA) is a long-standing matter of debate. In this work, we report our real-life experience with EGPA patients, treated with biologics targeting type 2 (T2)-eosinophilic inflammation (Mepolizumab, Benralizumab, Dupilumab). Interestingly, we observed …

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Cluster Analysis to Explore Clinical Subphenotypes of Eosinophilic Granulomatosis With Polyangiitis

Emma Rubenstein, Carla Maldini, Augusto Vaglio, Federica Bello et autres

Objective Previous studies suggested that distinct phenotypes of eosinophilic granulomatosis with polyangiitis (EGPA; formerly known as Churg-Strauss syndrome) could be determined by the presence or absence of antineutrophil cytoplasmic antibodies (ANCA), reflecting predominant vasculitic or eosinophilic processes, respectively. This study explored whether …

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Cluster Analysis To Explore Clinical Subphenotypes Of Eosinophilic Granulomatosis With Polyangiitis (Churg–Strauss)

Emma Rubenstein, Carla Maldini, Augusto Vaglio, Federica Bello et autres

Objective Previous studies suggested that distinct phenotypes of eosinophilic granulomatosis with polyangiitis (EGPA) could be determined by presence or absence of antineutrophil cytoplasmic antibodies (ANCA), reflecting predominant vasculitic or eosinophilic processes, respectively. This study explored whether ANCA-based clusters or other clusters can …

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OP0304 BENRALIZUMAB FOR EOSINOPHILIC GRANULOMATOSIS WITH POLYANGIITIS (EGPA): RESULTS FROM A EUROPEAN MULTICENTER STUDY ON 121 PATIENTS

Alessandra Bettiol, Irene Mattioli, Maria Letizia Urban, Federica Bello et autres

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AB0745 [18F]-FDG PET/CT IN LARGE VESSEL VASCULITIS: SEMI-QUANTITATIVE [18F]-FDG PET/CT ANALYSIS AND CORRELATION WITH DISEASE ACTIVITY

Paolo Fraticelli, G Ghirelli, M. Pasquinelli, Valentina Maurizi et autres

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Correction to: Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)

Luca Quartuccio, Alessandra Bortoluzzi, Carlo Alberto Scirè, Antônio Carlos Marangoni et autres

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Management of mixed cryoglobulinemia with rituximab: evidence and consensus-based recommendations from the Italian Study Group of Cryoglobulinemia (GISC)

Luca Quartuccio, Alessandra Bortoluzzi, Carlo Alberto Scirè, Antônio Carlos Marangoni et autres

Cryoglobulinemic vasculitis (CV) or mixed cryoglobulinemic syndrome (MCS) is a systemic small-vessel vasculitis characterized by the proliferation of B-cell clones producing pathogenic immune complexes, called cryoglobulins. It is often secondary to hepatitis C virus (HCV), autoimmune diseases, and hematological malignancies. CV usually …

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COVID-19 vaccination rate and safety profile in a multicentre Italian population affected by mixed cryoglobulinaemic vasculitis

Caterina Vacchi, Sofia Testoni, Marcella Visentini, Roberta Zani et autres

OBJECTIVES: Mixed cryoglobulinaemic vasculitis (MCV) is an immune-complex-mediated systemic vasculitis characterised by heterogeneous clinical manifestations mainly involving lymphatic system, skin, kidney and peripheral nervous system. Although MCV patients have been included in priority programs for vaccination against SARS-CoV-2 in Italy, limited information …

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Provisional recommendations for SARS-CoV-2 vaccination in patients with cryoglobulinaemic vasculitis

Salvatore Scarpato, Marco Sebastiani, Luca Quartuccio, Piero Marson et autres

People with cryoglobulinaemic vasculitis (CV) have an increased risk of infections, attributed to different causes: impairment of the immune system due to the disease itself, comorbidities, and immunosuppressive therapy. Therefore, these patients may be at high risk for a more severe course …

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Occupational Exposures and Smoking in Eosinophilic Granulomatosis With Polyangiitis: A Case–Control Study

Federica Maritati, Francesco Peyronel, Paride Fenaroli, Francesco Pegoraro et autres

OBJECTIVE: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Environmental agents and occupational exposures may confer susceptibility to EGPA, but data are scarce. This study was undertaken to investigate the association between occupational exposures (e.g., silica, farming, …

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Safety and effectiveness of biosimilar of Rituximab CT-P10 in the treatment of cryoglobulinemic vasculitis: the MARBLe study (Mixed cryoglobulinemiA Rituximab BiosimiLar)

Caterina Vacchi, Marcella Visentini, Laura Gragnani, Paolo Fraticelli et autres

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