COVID-19 vaccination rate and safety profile in a multicentre Italian population affected by mixed cryoglobulinaemic vasculitis
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
OBJECTIVES: Mixed cryoglobulinaemic vasculitis (MCV) is an immune-complex-mediated systemic vasculitis characterised by heterogeneous clinical manifestations mainly involving lymphatic system, skin, kidney and peripheral nervous system. Although MCV patients have been included in priority programs for vaccination against SARS-CoV-2 in Italy, limited information is available for these patients. The aims of this multicentre Italian study were to investigate SARS-CoV-2 vaccination rate in MCV patients and its safety profile. METHODS: All MCV patients referring to participating centres were assessed with an interview-based survey about vaccination, reasons for not getting vaccinated, adverse events (AE), and disease flares within a month after vaccination. RESULTS: A total of 416 patients were included in the study. Among participants, 7.7% did not get vaccinated, mainly for fear related to vaccine side-effects (50%) or medical decision (18.8%). They were more frequently treated with chronic glucocorticoids or rituximab (p=0.049 and p=0.043, respectively). Mild and self-limiting AE were recorded in 31.7% of cases, while post-vaccination vasculitis flares were observed in 5.3% of subjects. Disease relapses were mainly observed in patients with peripheral neuropathy or skin vasculitis (40% and 25%, respectively). CONCLUSIONS: Vaccination against SARS-CoV-2 has been performed in a high percentage of MCV patients with encouraging safety profile. Vasculitis flares rate was in line with that observed for other autoimmune diseases, despite patients with purpura or peripheral neuropathy seem to be at risk for symptoms' exacerbation. Patients' hesitancy, rituximab and glucocorticoids treatment were the main reasons for delaying vaccination.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- COVID-19 vaccination rate and safety profile in a multicentre Italian population affected by mixed cryoglobulinaemic vasculitis
- Date Crossref
- 18/03/2022
- Éditeur
- Clinical and Experimental Rheumatology
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Modena and Reggio Emilia Department of Surgery pays non établi dans la noticeUniversité ou école supérieure
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Sapienza University of Rome Department of Translational and Precision Medicine pays non établi dans la noticeUniversité ou école supérieure
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Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia pays non établi dans la noticeÉtablissement de santé
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University of Bari Aldo Moro Department of Biomedical Sciences and Human Oncology pays non établi dans la noticeUniversité ou école supérieure
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University of Florence pays non établi dans la noticeUniversité ou école supérieure
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Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda pays non établi dans la noticeÉtablissement de santé
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Centro di Riferimento Oncologico pays non établi dans la noticeÉtablissement de santé
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Istituti di Ricovero e Cura a Carattere Scientifico pays non établi dans la noticeÉtablissement de santé
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Marche Polytechnic University pays non établi dans la noticeUniversité ou école supérieure
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University of Udine Clinic of Rheumatology pays non établi dans la noticeUniversité ou école supérieure
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University of Padua pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Ospedale Civile di Legnano pays non établi dans la noticeÉtablissement de santé
Department of Surgery — University of Modena and Reggio Emilia, Department of Translational and Precision Medicine — Sapienza University of Rome et Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.