Mikhail V. Pavlov

Side-by-Side OCE-Study of Elasticity and SHG-Characterization of Collagen Fibers in Breast Cancer Tissue before and after Chemotherapy

Anton A. Plekhanov, Arseniy L. Potapov, Mikhail V. Pavlov, Vadim V. Elagin et autres

In the recent years promising results have been shown by the use of Compression optical coherence elastography (C-OCE) as a new optical biopsy approach to morphological assessment/diagnostics of human breast cancer using differences in elastic properties of morphological components of cancerous tissues. …

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Correction: Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy

Mikhail V. Pavlov, Anna P. Bavrina, Vladimir I. Plekhanov, German Yu. Golubyatnikov et autres

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Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy

Mikhail V. Pavlov, Anna P. Bavrina, Vladimir I. Plekhanov, German Yu. Golubyatnikov et autres

BACKGROUND: Breast cancer neoadjuvant chemotherapy (NACT) allows for assessing tumor sensitivity to systemic treatment, planning adjuvant treatment and follow-up. However, a sufficiently large number of patients fail to achieve the desired level of pathological tumor response while optimal early response assessment methods …

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Changes in the tumor oxygenation but not in the tumor volume and tumor vascularization reflect early response of breast cancer to neoadjuvant chemotherapy

Mikhail V. Pavlov, Anna P. Bavrina, Vladimir I. Plekhanov, German Yu. Golubyatnikov et autres

Abstract Background Breast cancer neoadjuvant chemotherapy (NACT) allows assessing tumor sensitivity to systemic treatment, planning adjuvant treatment and follow-up. However, a sufficiently large number of patients fail to achieve the desired level of pathological tumor response while optimal early response assessment methods …

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STUDY OF CHANGES IN TUMOR BLOOD FLOW FOR THE ASSESSMENT OF EARLY RESPONSE TO NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS

Mikhail V. Pavlov, П. И. Рыхтик, O. E. Ilyinskaya, Pavel Subochev et autres

Background. Over the past 20 years, there has been a change in approaches to the treatment of breast cancer, in particular, a significant increase in the role of drug therapy. Breast cancer response to neoadjuvant chemotherapy is currently considered as a surrogate …

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THE ROLE OF DIFFUSE OPTICAL SPECTROSCOPY IN THE DIAGNOSIS OF BREAST CANCER (CASE REPORT)

Mikhail V. Pavlov, S. A. Pegov, Anna Orlova, German Yu. Golubyatnikov et autres

Breast cancer (BC) is one of the most common malignancies and the leading cause of cancer-related death in women worldwide. Currently, mammography and ultrasound are the methods most commonly used for the detection of BC, but these methods have significant limitations in …

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Two-Photon Microscopy of Stroma ex vivo for the Express Diagnostics of Breast Cancer

Ekaterina A. Sergeeva, Mikhail Kirillin, Varvara V. Dudenkova, Mikhail V. Pavlov et autres

The goal of the study is to develop the approach for the express analysis of ex vivo biopsy specimens of breast tissue based on twophoton microscopy (TPM). Materials and Methods.We studied breast tissue samples obtained by trephine biopsy procedure.TPM images of breast …

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Small intestinal diverticula

Asfol'd Ivanovich Parfenov, Larisa M. Krums, Mikhail V. Pavlov

The prevalence of small intestinal diverticula (SID) in the population is 0.5-2.3%, and in most cases they are asymptomatic. In the presence of small intestinal bacterial overgrowth this results in chronic diarrhea and malabsorption. When it is complicated by diverticulitis it causes …

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Nonlinear Microscopy as a Tool of Express Biopsy in Breast Cancer Diagnostics

Ekaterina A. Sergeeva, Varvara V. Dudenkova, Sergey S. Kuznetsov, Mikhail Kirillin et autres

We demonstrate nonlinear microscopy (NLM) imaging of ex vivo breast tissue samples aimed at revealing pathological changes by observation of stroma reorganization. Numerical processing of NLM images is performed to evaluate the degree of collagen disorganization as the result of different pathologies.

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Multimodal approach in assessment of the response of breast cancer to neoadjuvant chemotherapy

Mikhail V. Pavlov, Tatiana Kalganova, Yekaterina Sergeevna Lyubimtseva

The ability for noninvasive visualization of functional changes of a tumor's oxygenation and circulatory system offers new advantages for prognosis and monitoring of the treatment efficacy. The results of breast cancer oxygen state study under chemotherapy action obtained by diffuse optical spectroscopy …

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The Complex Evaluation of Breast Cancer Metabolism and Blood Supply in Neoadjuvant Polychemotherapy

Mikhail V. Pavlov, Tatiana Kalganova, German Yu. Golubyatnikov, Vladimir I. Plekhanov et autres

Dynamics of breast tumor’s oxygenation and tumor blood flow during neoadjuvant chemotherapy was determined by diffuse optical spectroscopy and ultrasound investigation. Oxygenation and blood flow dynamics demonstrated variable changes depending on tumor response.

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The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer

Mikhail V. Pavlov, Pavel Subochev, Tatiana Kalganova, German Yu. Golubyatnikov et autres

Effective breast cancer treatment requires the assessment of metabolic changes of tumor tissue during chemo- and hormonotherapy for prediction tumor response. Evaluation of the dynamics of tumor oxygen state (by diffuse optical spectroscopy imaging) and tumor vasculature (by ultrasound investigation in power …

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