The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer
Rattachement africain : ru. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Effective breast cancer treatment requires the assessment of metabolic changes of tumor tissue during chemo- and hormonotherapy for prediction tumor response. Evaluation of the dynamics of tumor oxygen state (by diffuse optical spectroscopy imaging) and tumor vasculature (by ultrasound investigation in power Doppler mode) was performed before treatment beginning and before the second cycle of chemotherapy in 16 patients who received preoperative chemotherapy. Changes of these indicators were compared then with tumor pathologic response. Breast tumors demonstrated different dynamics of tumor oxygenation depending on the changes of tumor tissue. The increase of the tumor oxygenation after the first cycle of chemotherapy was observed in five of six patients with grade 4 and 5 of pathologic tumor response. Decrease of the oxygenation level was revealed in one patient with the 4th degree of tumor response. Variable changes of the oxygenation level were mentioned in the patients with moderate (the 3d degree) tumor response. Tumor oxygenation decreased or was unchanged in case of 1 or 2 degree of tumor response in five of six cases. The study of the tumor blood vessels didn't reveal any correlation between vasculature changes and tumor response under the performed treatment. The trend of tumor oxygenation in early time after treatment beginning might be a predictive criterion of tumor sensitivity to chemotherapy.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The complex evaluation of tumor oxygen state and vasculature during preoperative chemotherapy in patients with breast cancer
- Date Crossref
- 17/02/2017
- Éditeur
- SPIE
- Type
- proceedings-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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N. I. Lobachevsky State University of Nizhny Novgorod pays non établi dans la noticeUniversité ou école supérieure
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Regional Oncological Hospital (Russian Federation) pays non établi dans la noticeÉtablissement de santé
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Institute of Applied Physics (Russian Federation) pays non établi dans la noticeStructure de recherche
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State Medical Academy (Russian Federation) pays non établi dans la noticeInstitution
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N.I. Lobachevsky State Univ. of Nizhni Novgorod (Russian Federation) pays non établi dans la noticeInstitution
N. I. Lobachevsky State University of Nizhny Novgorod, Regional Oncological Hospital (Russian Federation) et Institute of Applied Physics (Russian Federation), avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.