Denis Gabriel

ABSTRACT NUMBER: ESOC2026A2223 EXTRACRANIAL DOPPLER ULTRASOUND HEMODYNAMIC PATTERNS ASSOCIATED WITH CARDIAC VALVULOPATHIES

R Domingos Da Costa Lopes, Maria Carlos Pereira, Carolina Gonçalves, Lénia Silva et autres

Abstract Background and aims Extracranial Doppler ultrasound (EDU) is widely used in stroke assessment, but whether carotid flow patterns reflect cardiac valvular disease is not established We aimed to identify Doppler hemodynamic patterns associated with valvulopathies and related markers. Methods Retrospective study …

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ABSTRACT NUMBER: ESOC2026A2488 ENDOVASCULAR TREATMENT IN LOW ASPECTS: REAL-WORLD DATA FROM A TERTIARY PORTUGUESE CENTER

Maria Carlos Pereira, Catarina Guedes Vaz, Gonçalo B Madureira, João Pedro Filipe et autres

Abstract Background and aims Randomized trials have demonstrated benefit from endovascular treatment (EVT) in acute ischaemic stroke with low ASPECTS. We evaluated functional outcomes after EVT in low-ASPECTS patients treated in routine clinical practice according to practitioners’ reasoning, and identified factors associated …

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Plasma Brain-Derived Tau in Prognosis of Large Vessel Occlusion Ischemic Stroke

Ricardo Varela, Fernando González‐Ortiz, Alexandre Dias, Nicoló Luca Knuth et autres

BACKGROUND: Large vessel occlusion acute ischemic stroke prognosis improved following the 2015 endovascular therapy (EVT) trials. Blood-based biomarkers may improve outcome prediction. We aimed to assess plasma brain-derived tau (BD-Tau) performance in predicting post-EVT large vessel occlusion acute ischemic stroke outcomes. METHODS: …

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Impact of SARS-CoV-2 Infection and Vaccination on Migraine Symptoms during the COVID-19 Pandemic

Lénia Silva, Adriana Rios Lopes, Ana Pontes, Ana Gonçalves et autres

Introduction: Studies have shown the worsening of migraine associated with the COVID-19 infection and the pandemic more broadly. COVID-19 vaccination has also been associated with symptomatic headache, with high frequency among migraineurs. We aimed to assess the impact of COVID-19 diagnosis and …

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Usability and feasibility of PreventS-MD web app for stroke prevention

Valery L. Feigin, Rita Krishnamurthi, Oleg N. Medvedev, Alexander Merkin et autres

BACKGROUND: Most strokes and cardiovascular diseases (CVDs) are potentially preventable if their risk factors are identified and well controlled. Digital platforms, such as the PreventS-MD web app (PreventS-MD) may aid health care professionals (HCPs) in assessing and managing risk factors and promoting …

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Impact of SARS-CoV-2 infection and vaccination on migraine symptoms during the COVID-19 pandemic

Lénia Silva, Adriana Rios Lopes, Ana Pontes, Ana R. Gonçalves et autres

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Fluid biomarkers in stroke: From animal models to clinical care

Alexandre Dias, Lénia Silva, João Moura, Denis Gabriel et autres

Stroke is a leading cause of death and disability worldwide. Stroke prevention, early diagnosis, and efficient acute treatment are priorities to successfully impact stroke death and disability. Fluid biomarkers may improve stroke differential diagnostic, patient stratification for acute treatment, and post-stroke individualized …

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Early plasma biomarker dynamic profiles are associated with acute ischemic stroke outcomes

Manuel A. Correia, Isabel Cristina Barbosa da Silva, Denis Gabriel, Joel Simrén et autres

BACKGROUND: Early outcome prediction after acute ischemic stroke (AIS) might be improved with blood-based biomarkers. We investigated whether the longitudinal profile of a multi-marker panel could predict the outcome of successfully recanalized AIS patients. METHODS: We used ultrasensitive single-molecule array (Simoa) to …

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Posterior Circulation Stroke: Coma (More Than Time) is Brain

Hugo Mota Dória, Gonçalo Videira, Daniel Ferreira, Pedro Castro et autres

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Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal

Mariana Carvalho Dias, Ricardo Soares-dos-Reis, João Vasco Santos, Ana Paiva Nunes et autres

INTRODUCTION: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim …

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Female preponderance in genetic generalized epilepsies

Gonçalo Videira, Denis Gabriel, Joel Freitas, Raquel Samões et autres

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Matrix Metalloproteinase-9 Levels are Associated with Brain Lesion and Persistent Venous Occlusion in Patients with Cerebral Venous Thrombosis

Diana Aguiar de Sousa, Maria Conceição Pereira Santos, Ana Serra‐Caetano, Lia Lucas Neto et autres

Abstract Background Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood–brain barrier …

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