Matrix Metalloproteinase-9 Levels are Associated with Brain Lesion and Persistent Venous Occlusion in Patients with Cerebral Venous Thrombosis
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Le résumé fourni par la source
Abstract Background Elucidating mechanisms of brain damage in cerebral venous thrombosis (CVT) would be instrumental to develop targeted therapies and improve prognosis prediction. Matrix metalloproteinase-9 (MMP-9), a gelatinase that degrades major components of the basal lamina, has been associated to blood–brain barrier disruption. We aimed to assess, in patients with CVT, the temporal change in serum concentrations of MMP-9 and its association with key imaging and clinical outcomes. Methods Pathophysiology of Venous Infarction—PRediction of InfarctiOn and RecanalIzaTion in CVT (PRIORITy-CVT) was a multicenter prospective cohort study of patients with newly diagnosed CVT. Serial collection of peripheral blood samples performed on day 1, 3, and 8, and standardized magnetic resonance imaging on day 1, 8, and 90. MMP-9 was quantified using enzyme-linked immunosorbent assay in 59 patients and 22 healthy controls. Primary outcomes were parenchymal brain lesion, early evolution of brain lesion, early recanalization, and functional outcome on day 90. Results CVT patients with parenchymal brain lesion had higher baseline concentrations of MMP-9 compared with controls (adjusted p = 0.001). The area under receiver operating characteristic curve value for MMP-9 for predicting brain lesion was 0.71 (95% confidence interval [CI]: 0.57–0.85, p = 0.009). Patients with venous recanalization showed early decline of circulating MMP-9 and significantly lower levels on day 8 (p = 0.021). Higher MMP-9 on day 8 was associated with persistent venous occlusion (odds ratio: 1.20 [per 20 ng/mL], 95% CI: 1.02–1.43, p = 0.030). Conclusion We report a novel relationship among MMP-9, parenchymal brain damage, and early venous recanalization, suggesting that circulating MMP-9 is a dynamic marker of brain tissue damage in patients with CVT.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Matrix Metalloproteinase-9 Levels are Associated with Brain Lesion and Persistent Venous Occlusion in Patients with Cerebral Venous Thrombosis
- Date Crossref
- 23/03/2021
- Éditeur
- Georg Thieme Verlag KG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Lisbon Institute of Anatomy pays non établi dans la noticeUniversité ou école supérieure
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Hospital de Santa Maria pays non établi dans la noticeÉtablissement de santé
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Unidade Local de Saúde de Entre Douro e Vouga pays non établi dans la noticeÉtablissement de santé
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Hospital da Luz Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Universidade do Porto pays non établi dans la noticeUniversité ou école supérieure
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Hospital de São João pays non établi dans la noticeÉtablissement de santé
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Universidade de Lisboa Department of Neurosciences and Mental Health (Neurology) pays non établi dans la noticeUniversité ou école supérieure
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Centro Hospitalar de Entre Douro e Vouga Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Centro Hospitalar Universitário do Porto - Hospital Santo António Department of Neurology pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
Institute of Anatomy — University of Lisbon, Hospital de Santa Maria et Unidade Local de Saúde de Entre Douro e Vouga, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.