Tokuzo Minouchi

Effect of blood decrease on micafungin disposition in rats

Hiroki Konishi, Keizo Fukushima, Masatomo Sudo, Masaki Sumi et autres

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Impact of Plasma Exchange on Pharmacokinetic Disposition of Micafungin

Hiroki Konishi, Keizo Fukushima, Takao Saotome, Tetsu Hamamoto et autres

Change in the pharmacokinetic disposition of an antifungal agent micafungin (MCFG) by 8-hour plasma exchange (PE) with 3200 mL replacement was examined in a stem cell transplant recipient. On pharmacokinetic analysis of the time course of the serum concentrations of MCFG, it …

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Reduced elimination clearance of micafungin in rats with cholestatic hyperbilirubinemia

Hiroki Konishi, Keizo Fukushima, Masatomo Sudo, Masaki Sumi et autres

We examined whether the pharmacokinetic disposition of micafungin (MCFG), an echinocandin class antifungal agent, is altered in hyperbilirubinemia using a rat model prepared by bile duct ligation (BDL). Serum bilirubin levels were increased depending upon the duration of BDL. The elimination rate …

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Change in blood tacrolimus concentration by fluctuation of renal function in a bone marrow transplant patient

Masaki Sumi, Hiroki Konishi, Yoshihiro Ikuno, Nobuo Hoshino et autres

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Withdrawal symptom after discontinuation of transdermal fentanyl at a daily dose of 0.6 mg

Chie Ishihara, Hiroki Konishi, Mikio Chiba, Tokuzo Minouchi et autres

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Pharmacokinetic Behavior of Micafungin in Rats with Carbon Tetrachloride-Induced Acute Hepatic Failure

Hiroki Konishi, Masatomo Sudo, Masaki Sumi, Hiroaki Morii et autres

We examined the pharmacokinetic behavior of micafungin, a novel antifungal agent, in rats receiving carbon tetrachloride (CCl4) at a single dose of 2.5 ml/kg. There was no significant change in the total clearance (CL(tot)) in CCl4-treated rats, while the steady-state volume of …

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Unusual hypersensitivity to warfarin in a critically ill patient

Hiroki Konishi, Yawara Eguchi, Mika Fujii, Takao Saotome et autres

A patient was admitted to the intensive care unit because of respiratory failure, and warfarin therapy was started at 2 mg/day for the treatment of pulmonary embolism, together with other medications. Despite the low dosage of warfarin, international normalized ratio (INR) was …

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Decrease in oral bioavailability of ciclosporin by intravenous pulse of methylprednisolone succinate in rats

Hiroki Konishi, Masaki Sumi, Nobuhito Shibata, Kanji Takada et autres

We examined the effects of high-dose methylprednisolone on the bioavailability of orally administered ciclosporin in rats. To emulate the clinical protocol of methylprednisolone pulse therapy, methylprednisolone sodium succinate (MPS), a prodrug of methylprednisolone, was intravenously administered as repeated doses (66.3 mg kg(-1)) …

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Urinary 6 β -hydroxycortisol/17-hydroxycorticosteroids ratio as a measure of hepatic CYP3A4 capacity after enzyme induction

Hiroki Konishi, Tanaka Kazuhiko, Tokuzo Minouchi, Akira Yamaji

BACKGROUND: The correlation between the urinary 6beta-hydroxycortisol/17-hydroxycorticosteroids (6beta-OHF/17-OHCS) ratio and the metabolic capacity of the most abundant form of hepatic cytochrome P450 (CYP3A4) after induction remains unclear. METHODS: Concentrations of 6beta-OHF and 17-OHCS in spot urine specimens obtained from 61 epileptic children …

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Influence of intravenous methylprednisolone pulse treatment on the disposition of ciclosporin and hepatic CYP3A activity in rats

Hiroki Konishi, Masaki Sumi, Tokuzo Minouchi, Akira Yamaji et autres

We examined the effects of high-dose methylprednisolone (MP) on the disposition of ciclosporin (CsA) and hepatic microsomal CYP3A activity using rats. Methylprednisolone sodium succinate (MPS), a prodrug of MP, was intravenously administered as repeated doses (66.3 mg kg(-1)) for 3 days or …

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Serum carvedilol concentration and its relation to change in plasma brain natriuretic peptide level in the treatment of heart failure: a preliminary study

Hiroki Konishi, Shin Nishio, Takayoshi Tsutamoto, Tokuzo Minouchi et autres

OBJECTIVE: To examine the influence of carvedilol dose and concentration in serum on plasma brain natriuretic peptide (BNP), a measure of heart failure progression. METHODS: 12 patients with New York Heart Association (NYHA) functional class II-III chronic heart failure were enrolled in …

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Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats

Hiroki Konishi, Takashi Yoshimoto, Kunihiko Morita, Tokuzo Minouchi et autres

It has been found in clinical practice that the serum level of phenytoin, of which metabolism is mediated by hepatic CYP2C enzymes, was markedly elevated by co-administration of 5-fluorouracil (5-FU) and doxifluridine (5'-deoxy-5-fluorouridine; 5'-DFUR), a prodrug of 5-FU, but the detailed mechanisms …

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