Accès ouvert
2026
article
OpenAlex
Beibei Wu, Spyridon Hasiakos, Shawn Cokus, Matthew Do et autres
(CRAC) channels for their effector function. Here, we demonstrate that Th17 cells are uniquely sensitive to temporal inhibition of CRAC channels. Temporal CRAC channel block disturbed the effector functions and metabolic programming of Th17 cells, which were rescued by MYC expression. We …
us
(code pays fourni par la source)
2026
preprint
OpenAlex
Ethan Eurmsirilerd, Mariano Resendiz, Giuseppe Lana, Qing Li et autres
Abstract Common wheat ( Triticum aestivum L.) is a cornerstone of global food security. However, the standard reference genome, IWGSC RefSeq v2.1, is derived from wheat cultivar Chinese Spring, a historically important lineage that is not representative of modern cultivated wheat. In …
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(code pays fourni par la source)
Accès ouvert
2026
preprint
OpenAlex
Xuekai Xiong, Jemima Pangemanan, Tali Kiperman, Zuoming Sun et autres
The circadian clock maintains temporal control of metabolic processes and exerts a key role in adipocyte development. Discovery of clock-modulatory compounds may provide new avenues for metabolic disease therapy. Here we report the identification of flavonoid compounds, Quercetin and Fisetin, as clock-activating …
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Accès ouvert
2026
article
OpenAlex
Xuekai Xiong, Jemima Pangemanan, Tali Kiperman, Zuoming Sun et autres
The circadian clock orchestrates adipocyte development and lipid remodeling, with its disruption leading to the development of obesity and insulin resistance. Here we demonstrate that the flavonoid compound naringenin displays clock modulatory activity that suppresses adipocyte lipid storage while promoting browning. In …
us
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Accès ouvert
2025
supplementary-materials
OpenAlex
Xiancai Zhong, Hongmin Wu, Ching Ouyang, Wencan Zhang et autres
All supplementray figures and tables
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Accès ouvert
2025
article
OpenAlex
Zuoming Sun
Abstract Description Recurrent somatic mutations in spliceosome factor 3b subunit 1 (SF3B1) are identified in hematopoietic cell-derived malignancies, with SF3B1-K700E being the most common one. Here we show that Treg specific expression of SF3B1-K700E (Sf3b1K700Efl/+/Foxp3YFP-Cre) results in spontaneous autoimmune phenotypes including enlarged …
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Accès ouvert
2025
article
OpenAlex
Zuoming Sun
Abstract Description Recurrent somatic mutations in spliceosome factor 3b subunit 1 (SF3B1) are identified in hematopoietic cell-derived malignancies, with SF3B1-K700E being the most common one. Here we show that Treg specific expression of SF3B1-K700E (Sf3b1K700Efl/+/Foxp3YFP-Cre) results in spontaneous autoimmune phenotypes including enlarged …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Ke Ma, Xuekai Xiong, Jemima Pangemanan, Tali Kiperman et autres
The circadian clock orchestrates adipocyte development and lipid remodeling, with its disruption leading to the development of obesity and insulin resistance. Here we demonstrate that the flavonoid compound naringenin displays clock modulatory activity via RORα that suppresses adipocyte lipid storage while promoting …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Xiancai Zhong, Hongmin Wu, Guanpeng Wang, Zuoming Sun
Studying the cis -regulatory elements (CREs) of genes in Th17 cells during autoimmune disease progression, such as experimental autoimmune encephalomyelitis (EAE), is often limited by the availability of gene-edited mice. Here, we present a protocol for CRISPR-mediated deletion of a CRE in …
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Accès ouvert
2025
article
OpenAlex
Beibei Wu, Jin Seok Woo, Spyridon Hasiakos, Calvin Pan et autres
Genetic and environmental factors shape an individual's susceptibility to autoimmunity. To identify genetic variations regulating effector T cell functions, we used a forward genetics screen of inbred mouse strains and uncovered genomic loci linked to cytokine expression. Among the candidate genes, we …
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Accès ouvert
2024
article
OpenAlex
Xiancai Zhong, Hongmin Wu, Wencan Zhang, Yunying Shi et autres
T helper (Th)17 cells mediate both protective anti-bacterial immune responses and autoimmune pathogenesis, but the distinct pathways regulating these Th17 responses remain unclear. Retinoid-related orphan receptor γ t (RORγt) is a master transcription factor that governs Th17 cell generation and effector functions. …
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Accès ouvert
2024
article
OpenAlex
Yun Shi, Wencan Zhang, Qiong Jia, Xiancai Zhong et autres
Recurrent somatic mutations in spliceosome factor 3b subunit 1 (SF3B1) are identified in hematopoietic malignancies, with SF3B1-K700E being the most common one. Here, we show that regulatory T cell (T reg )–specific expression of SF3B1-K700E ( Sf3b1 K700Efl/+ /Foxp3 YFP-Cre ) results …
us
(code pays fourni par la source)