Jéssica Pires Farias

AlOH and AlP Adjuvants Promote Stimulation and Phagocytosis in RAW 264.7: New Findings in Particle Size, Buffers, and Antigen Adsorption

Georon Ferreira de Sousa, Jéssica Pires Farias, Kalil Cristhian Figueiredo Toledo, Eduardo Gimenes Martins et autres

Introduction: Aluminum adjuvants are essential components of many vaccines, enhancing antigen delivery and stimulating immune cell activation. While their long history of use underscores their effectiveness, understanding the optimal conditions for antigen adsorption remains a challenge. This study aimed to investigate the …

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Transformando o invisível em tangível: estudo de caso sobre o uso de maquetes táteis para inclusão no ensino de bacteriologia

Carolina Diorio Nastaro, Jéssica Pires Farias, Bruna Rodrigues Correa, Shirley Rodrigues Maia et autres

O ensino de microbiologia apresenta barreiras importantes para alunos com deficiência visual, dada a forte dependência de recursos visuais. Para promover acessibilidade e inclusão, foi desenvolvido o BacTátil, um kit composto por 24 maquetes táteis que representam conteúdos fundamentais da bacteriologia. O …

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Standardization of C6/36 cells for DENV-2 virological assays: isolation, TCID₅₀ and serum neutralization

Elmo José dos Santos, Amanda da Rocha Santos, Mayanna Moreira Costa Fogaça, Naiara Soares da Silva et autres

OBJECTIVE: This study aimed the standardization of detection, isolation, titration, replication kinetics, and virus neutralization assay protocols for DENV-2 (New Guinea C strain) with the C6/36 mosquito-derived cell line. RESULTS: DENV-2 was isolated, titrated by TCID₅₀, and quantified via molecular assays using …

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ATR-FTIR spectroscopy and chemometric analysis as highly sensitive detection tool for SARS-CoV-2 infection in saliva from different types of COVID-19 severity

Jéssica Pires Farias, Paulo Henrique Gonçalves Dias Diniz, David Douglas de Sousa Fernandes, Luís Carlos de Souza Ferreira et autres

Rapid, non-invasive, and scalable diagnostic tools are essential for managing respiratory viral infections and enhancing pandemic preparedness. While vibrational spectroscopy coupled with chemometrics has emerged as a powerful biosensing tool, many SARS-CoV-2 studies remain constrained by limited sample sizes and narrow clinical …

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Antigenic drift in SARS-CoV-2: diminished vaccine protection in pediatric populations against Omicron and its JN.1 subvariant

Jéssica Pires Farias, Milena Silva Souza, Mayanna Moreira Costa Fogaça, Ruth Dálety da Silva Brito et autres

Background The COVID-19 vaccination campaign for children in Brazil evolved gradually from 2021 to the present, adapting to regulatory framework from the Brazilian Health Regulatory Agency (ANVISA). However, while adults received updated vaccines targeting newer variants, children and adolescents continued to receive …

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T-Cell Epitope-Based SARS-CoV-2 DNA Vaccine Encoding an Antigen Fused with Type 1 Herpes Simplex Virus Glycoprotein D (gD)

Luana R. M. M. Aps, Aléxia Adrianne Venceslau-Carvalho, Carla Longo de Freitas, Bruna F.M.M. Porchia et autres

Authorized SARS-CoV-2 vaccines elicit both antibody and T-cell responses; however, benchmark correlates and update decisions have largely emphasized neutralizing antibodies. Motivated by the complementary role of cellular immunity, we designed a prototype polyepitope DNA vaccine encoding conserved human and mouse T-cell epitopes …

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Declining COVID-19 vaccination coverage in Brazil: A global health warning

Milena Silva Souza, Jéssica Pires Farias, Luís Carlos de Souza Ferreira, Jaime Henrique Amorim

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An Update on Anti-COVID-19 Vaccines and the Challenges to Protect Against New SARS-CoV-2 Variants

Fábio Mambelli, Ana Carolina V. S. C. de Araujo, Jéssica Pires Farias, Kívia Queiroz de Andrade et autres

The COVID-19 pandemic has posed a significant threat to global health systems, with extensive impacts across many sectors of society. The pandemic has been responsible for millions of deaths worldwide since its first identification in late 2019. Several actions have been taken …

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Findings and outcomes of hospitalized unvaccinated patients during the COVID-19 pandemic: impact of comorbidities on clinical, laboratory, and immunological parameters

Georon Ferreira de Sousa, Jéssica Pires Farias, Bárbara Rafaela da Silva Barros, Danilo Bancalero Mendonça Lucchi et autres

The COVID-19 pandemic continues to highlight the significant impact of pre-existing comorbidities on disease progression and patient outcomes due to the risk factors for severe disease in unvaccinated patients. We evaluated the association between several clinical/laboratory findings and comorbidities in a cohort …

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Beyond the Amazon: vector surveillance and emerging Oropouche virus in South America

Jéssica Pires Farias, Alexander Birbrair, Luís Carlos Souza Ferreira, Paloma Oliveira Vidal et autres

Ruth Dálety Silva Brito, Jéssica Pires Farias, Alexander Birbrair, Luís Carlos Souza Ferreira, Paloma Oliveira Vidal, Jaime Henrique Amorim; Beyond the Ama

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Serotype‐Specific Dengue Virus IgG Assay Using EDIII‐Based Recombinant Proteins and Its Application in an Endemic Population in Northeast Brazil

Samuel Santos Pereira, Rafael Rahal Guaragna Machado, Jéssica Pires Farias, Robert Andreata‐Santos et autres

Dengue is the most prevalent arboviral disease globally, with Brazil currently experiencing a significant rise in cases. Dengue virus (DENV) typically co-circulates with other clinically and antigenically similar flaviviruses, such as Zika virus (ZIKV). The clinical diagnosis is difficult and accurate serological …

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Advancing dengue vaccination using a T-cell priming peptide approach

Jéssica Pires Farias, Alexander Birbrair, Jaime Henrique Amorim

The persistent battle against dengue has been characterized by the formidable challenges posed by the virus's complex serotypes and the concerning risks associated with antibody-dependent enhancement (ADE) of infection, a phenomenon observed in some vaccine candidates targeting the envelope glycoprotein.1 In contributing …

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