Accès ouvert
2025
article
OpenAlex
Hyunjong Byun, Han Sai Lee, Young Shin Song, Young Joo Park
Background: Although patients with anaplastic thyroid cancer (ATC) generally have a poor prognosis and there are currently no effective treatment options, survival and response to therapy vary between patients. Genomic and transcriptomic profiles of ATC have been reported; however, a comprehensive study …
kr, Éthiopie
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Accès ouvert
2024
article
OpenAlex
Yerin Kim, D. Kim, Nguyen-Mihn Hieu, Hyunjong Byun et autres
BACKGROUND: The process of producing proteins in bacterial systems and secreting them through ATP-binding cassette (ABC) transporters is an area that has been actively researched and used due to its high protein production capacity and efficiency. However, some proteins are unable to …
kr
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Accès ouvert
2022
article
OpenAlex
Hyunjong Byun, Jiyeon Park, Benedict U. Fabia, Joshua Bingwa et autres
Many heterologous proteins can be secreted by bacterial ATP-binding cassette (ABC) transporters, provided that they are fused with the C-terminal signal sequence, but some proteins are not secretable even though they carry the right signal sequence. The invention of a method to …
kr
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Accès ouvert
2019
article
OpenAlex
Jae-Wook Ryu, Hyunjong Byun, Joseph P. Park, Jiyeon Park et autres
We observed that the S. antibioticus extracellular tyrosinase secretion level was even higher in its nonnatural translationally conjugated fusion protein form than in the natural complex of two separated polypeptides. The results of this study demonstrate that tyrosinase-expressing P. fluorescens can be …
kr
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Accès ouvert
2017
article
OpenAlex
Hyunjong Byun, Jiyeon Park, Sun Chang Kim, Jung Hoon Ahn
Efficient protein production for industrial and academic purposes often involves engineering microorganisms to produce and secrete target proteins into the culture. Pseudomonas fluorescens has a TliDEF ATP-binding cassette transporter, a type I secretion system, which recognizes C-terminal LARD3 signal sequence of thermostable …
kr
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