Han Sai Lee

Mitochondrial DNA mutations drive tumor heterogeneity in papillary thyroid carcinoma

Han Sai Lee, Jinsun Lim, Jin Hyung Heo, Hak Hoon Jun et autres

Tumor heterogeneity presents a major challenge to understanding cancer evolution and therapeutic resistance in thyroid cancer. While previous studies have focused on nuclear driver mutations, the role of mitochondrial DNA (mtDNA) alterations in this heterogeneity remains elusive. Through multi-regional whole-genome and transcriptome …

kr (code pays fourni par la source)

Mutation-Specific Dynamics of Dedifferentiation Trajectories and Tumor–Stromal Interactions in Thyroid Cancer

Eun Hye Joo, Young Shin Song, Han Sai Lee, Gyeongseo Jung et autres

kr, Éthiopie (code pays fourni par la source)

Transcriptome of Anaplastic Thyroid Cancer Reveals Two Molecular Subtypes with Distinct Tumor Microenvironment and Prognosis

Hyunjong Byun, Han Sai Lee, Young Shin Song, Young Joo Park

Background: Although patients with anaplastic thyroid cancer (ATC) generally have a poor prognosis and there are currently no effective treatment options, survival and response to therapy vary between patients. Genomic and transcriptomic profiles of ATC have been reported; however, a comprehensive study …

kr, Éthiopie (code pays fourni par la source)

Mitophagy Defects Exacerbate Inflammation and Aberrant Proliferation in Lymphocytic Thyroiditis

Han Sai Lee, Jinju Lee, Hyun‐Ju An, Min Ji Sung et autres

Background: Mitochondrial dysfunction in the thyroid due to defective mitophagy has been observed in lymphocytic thyroiditis (LT). However, the effect of impaired mitophagy on the pathogenesis of LT is not well understood. The aim of this study is to investigate the role …

kr (code pays fourni par la source)

Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks

Wenjing Chen, Young Shin Song, Han Sai Lee, Chien‐Wei Lin et autres

us, kr (code pays fourni par la source)

Clinicopathological Features and Molecular Signatures of Lateral Neck Lymph Node Metastasis in Papillary Thyroid Microcarcinoma

Jinsun Lim, Han Sai Lee, Jin Hyung Heo, Young Shin Song

BACKGRUOUND: The predictive factors for lateral neck lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC) remain undetermined. This study investigated the clinicopathological characteristics, transcriptomes, and tumor microenvironment in PTMC according to the LLNM status. We aimed to identify the biomarkers associated …

kr (code pays fourni par la source)

Estrogen-related receptor alpha promotes thyroid tumor cell survival via a tumor subtype-specific regulation of target gene networks

Wenjing Chen, Young Shin Song, Han Sai Lee, Chien-Wei Lin et autres

Abstract Mortalin (encoded by HSPA9) is a mitochondrial chaperone often overexpressed in cancer through as-yet-unknown mechanisms. By searching different RNA-sequencing datasets, we found that ESRRA is a transcription factor highly correlated with HSPA9 in thyroid cancer, especially in follicular, but not C …

us, kr (code pays fourni par la source)

Mitophagy defects exacerbate inflammation and aberrant proliferation in lymphocytic thyroiditis

Han Sai Lee, Jinju Lee, Hyun‐Ju An, Min Ji Sung et autres

Abstract Background Mitochondrial dysfunction of the thyroid due to defective mitophagy has been observed in lymphocytic thyroiditis (LT). However, the effect of impaired mitophagy on the pathogenesis of LT has not been elucidated. Results We investigated the molecular pathological effect of mitophagy …

kr (code pays fourni par la source)

Different Molecular Phenotypes of Progression in BRAF- and RAS-Like Papillary Thyroid Carcinoma

Jinsun Lim, Han Sai Lee, Jiyun Park, Kyung‐Soo Kim et autres

BACKGRUOUND: Papillary thyroid carcinoma (PTC) can be classified into two distinct molecular subtypes, BRAF-like (BL) and RASlike (RL). However, the molecular characteristics of each subtype according to clinicopathological factors have not yet been determined. We aimed to investigate the gene signatures and …

kr (code pays fourni par la source)

Abstract P5-05-08: CXCL16 as a potential therapeutic target of triple-negative breast cancer

Sun Wook Cho, Mi Jang, Hyun Jin Sun, Han Sai Lee et autres

Abstract CXCL16, as a chemotactic cytokine, promotes cancer proliferation, migration, and immune cell infiltration in tumor microenvironment. However, CXCL16 has been shown to play a conflicting role in breast cancer. The aim of this study was to investigate the therapeutic potential of …

kr (code pays fourni par la source)