Montserrat Agut

Quantitative Imaging of Human Hemoglobin Binding to Staphylococcus aureus With Single‐Molecule Resolution

Pietro Delcanale, Andrea Mussini, Òscar Gulías, Montserrat Agut et autres

Staphylococcus aureus is a widespread human pathogenic bacterium that poses an increasingly serious threat to public health worldwide, due to the emergence and spread of antibiotic-resistant strains. A key virulence mechanism is the acquisition of iron from the heme group of human …

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Light Meets Nature: Cellulose Cluster as a Natural Photoantimicrobial Agent

Karina Dueñas‐Parro, Òscar Gulías, Beatriz Artalejo, Montserrat Agut et autres

Antibiotic‐resistant bacteria present a persistent challenge to current therapeutic methods, underscoring the need for novel antimicrobial approaches. Antimicrobial photodynamic therapy (aPDT) is a promising approach that uses reactive oxygen species to damage bacterial membranes, proteins and nucleic acids, making it difficult for …

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Cluster and Kill: the Use of Clustering‐Triggered Emission Materials for Singlet Oxygen Photosensitization in Antimicrobial Photodynamic Therapy

Karina Dueñas‐Parro, Òscar Gulías, Montserrat Agut, Felipe de la Cruz‐Martínez et autres

Abstract The emergence of light‐based technologies is revolutionizing modern medicine and healthcare by enabling precise disease diagnosis and treatment through various luminescent agents and imaging techniques. Despite challenges like biocompatibility, spectral tuning, and synthesis complexity, the primary issue is the aggregation‐caused quenching …

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Concanavalin A Delivers a Photoactive Protein to the Bacterial Wall

Andrea Mussini, Pietro Delcanale, M Berni, Stefano Pongolini et autres

Modular supramolecular complexes, where different proteins are assembled to gather targeting capability and photofunctional properties within the same structures, are of special interest for bacterial photodynamic inactivation, given their inherent biocompatibility and flexibility. We have recently proposed one such structure, exploiting the …

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A Double Payload Complex between Hypericin and All-trans Retinoic Acid in the β-Lactoglobulin Protein

Beatriz Rodríguez-Amigo, Cormac Hally, Núria Roig-Yanovsky, Pietro Delcanale et autres

Combined therapies are usually used to treat acne vulgaris since this approach can tackle various foci simultaneously. Using a combination of spectroscopic, computational, and microbiological techniques and methods, herein we report on the use of β-lactoglobulin as a double payload carrier of …

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Photosensitive EGFR-Targeted Nanocarriers for Combined Photodynamic and Local Chemotherapy

Elena de las Heras, M. Lluïsa Sagristá, Montserrat Agut, Santi Nonell

The major limitation of any cancer therapy lies in the difficulty of precisely controlling the localization of the drug in the tumor cells. To improve this drawback, our study explores the use of actively-targeted chemo-photo-nanocarriers that recognize and bind to epidermal growth …

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Self‐Assembled Binaphthyl‐Bridged Amphiphilic AABB Phthalocyanines: Nanostructures for Efficient Antimicrobial Photodynamic Therapy

Miguel A. Revuelta‐Maza, Elena de las Heras, Montserrat Agut, Santi Nonell et autres

Pcs (PS-1 and PS-2), with an AABB geometry (where A and B refer to differently substituted isoindole constituents). They contain differently functionalized, chiral binaphthyloxy-linked A isoindole units, which determine the hydrophobicity of the system, and cationic methyl pyridinium moieties in the other …

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Tetramethylbenzidine: An Acoustogenic Photoacoustic Probe for Reactive Oxygen Species Detection

Roger Bresolí‐Obach, Marcello Frattini, Stefania Abbruzzetti, Cristiano Viappiani et autres

Photoacoustic imaging is attracting a great deal of interest owing to its distinct advantages over other imaging techniques such as fluorescence or magnetic resonance image. The availability of photoacoustic probes for reactive oxygen and nitrogen species (ROS/RNS) could shed light on a …

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Tetramethylbenzidine: A Photoacoustic Probe for Reactive Oxygen Species Detection

Roger Bresolí‐Obach, Marcello Frattini, Stefania Abbruzzetti, Cristiano Viappiani et autres

Photoacoustic imaging is attracting a great deal of interest owing to its distinct advantages over other imaging techniques such as fluorescence or magnetic resonance image. Availability of photoacoustic probes for reactive oxygen and nitrogen species (ROS/RNS) could shed light on a plethora …

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c(RGDfK)‐ and ZnTriMPyP‐Bound Polymeric Nanocarriers for Tumor‐Targeted Photodynamic Therapy

Elena de las Heras, Ester Boix‐Garriga, Francesca Bryden, Montserrat Agut et autres

Abstract Active targeting strategies are currently being extensively investigated in order to enhance the selectivity of photodynamic therapy. The aim of the present research was to evaluate whether the external decoration of nanopolymeric carriers with targeting peptides could add more value to …

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Effective Photodynamic Inactivation of 26 Escherichia coli Strains with Different Antibiotic Susceptibility Profiles: A Planktonic and Biofilm Study

Òscar Gulías, Giselle McKenzie, Miquel Bayó, Montserrat Agut et autres

The emergence of multidrug-resistant bacteria is a growing problem and alternative therapies are being sought to effectively address this issue. The aim of this study is to assess a range of Escherichia coli strains’ susceptibility to Methylene Blue-mediated antimicrobial photodynamic therapy and …

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A porphycene-gentamicin conjugate for enhanced photodynamic inactivation of bacteria

Ingrid Nieves, Cormac Hally, Cristiano Viappiani, Montserrat Agut et autres

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