Michael J. Farrell

A Deterministic Architecture for Pre-Execution Governance

Michael J. Farrell

AI systems increasingly operate in environments where governance cannot be retrofitted after execution. Policy documents, constitutional alignment, post-hoc audits, runtime guardrails and reactive shutdown mechanisms share a structural defect: they act too late, on the wrong layer, or with signals that are …

ca (code pays fourni par la source)

A Deterministic Architecture for Pre-Execution Governance

Michael J. Farrell

AI systems increasingly operate in environments where governance cannot be retrofitted after execution. Policy documents, constitutional alignment, post-hoc audits, runtime guardrails and reactive shutdown mechanisms share a structural defect: they act too late, on the wrong layer, or with signals that are …

ca (code pays fourni par la source)

What Vague Instructions Cost an AI Agent: A Controlled Test of Deterministic Pre-Execution Clarity Screening

Michael J. Farrell

Sixty agentic instructions with deposited intent were executed by a tool-enabled LLM agent and hand-scored against per-instruction checklists. Unscreened, the agent completed the depositor's intent in 25 % of runs — 100 % on determinate instructions, 0 % on underspecified ones: the …

ca (code pays fourni par la source)

What Vague Instructions Cost an AI Agent: A Controlled Test of Deterministic Pre-Execution Clarity Screening

Michael J. Farrell

Sixty agentic instructions with deposited intent were executed by a tool-enabled LLM agent and hand-scored against per-instruction checklists. Unscreened, the agent completed the depositor's intent in 25 % of runs — 100 % on determinate instructions, 0 % on underspecified ones: the …

ca (code pays fourni par la source)

Structural Input Clarity as a Behavioral Stabilizer for Large Language Models

Michael J. Farrell

Structural Input Clarity as a Behavioral Stabilizer for Large Language Models presents a position statement responding to Anthropic’s April 2026 research on functional emotions in Claude Sonnet 4.5. The paper argues that Anthropic’s discovery of 171 causally active emotional vectors, especially the …

Structural Input Clarity as a Behavioral Stabilizer for Large Language Models

Michael J. Farrell

Structural Input Clarity as a Behavioral Stabilizer for Large Language Models presents a position statement responding to Anthropic’s April 2026 research on functional emotions in Claude Sonnet 4.5. The paper argues that Anthropic’s discovery of 171 causally active emotional vectors, especially the …

A Deterministic Architecture for Pre-Execution Governance

Michael J. Farrell

Artificial intelligence systems require reliable pre-execution mechanisms to ensure contextualintegrity, traceability, and internal coherence before actions are carried out. Terms such asclarity and awareness are frequently used in governance discourse, yet they are rarelyformalized in operational terms.This paper introduces PREEXEC™, a deterministic …

A Deterministic Architecture for Pre-Execution Governance

Michael J. Farrell

Artificial intelligence systems require reliable pre-execution mechanisms to ensure contextualintegrity, traceability, and internal coherence before actions are carried out. Terms such asclarity and awareness are frequently used in governance discourse, yet they are rarelyformalized in operational terms.This paper introduces PREEXEC™, a deterministic …

A Deterministic Architecture for Pre-Execution Governance

Michael J. Farrell

Artificial intelligence systems require reliable pre-execution mechanisms to ensure contextualintegrity, traceability, and internal coherence before actions are carried out. Terms such asclarity and awareness are frequently used in governance discourse, yet they are rarelyformalized in operational terms.This paper introduces PREEXEC™, a deterministic …

Placebo effect on brainstem activity associated with capsaicin-evoked urge to cough in healthy humans

Aung Aung Kywe Moe, Tara G. Bautista, Jennifer Leech, Stuart B. Mazzone et autres

Background Placebo effects are common in studies of cough and antitussive medications, suggestive of a profound influence of brain activity over cough neural processing. We previously reported placebo intervention-associated reductions in the urge-to-cough and the associated higher order brain network activity evoked …

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A complex and severe encephalitis associated with four co-existing neuronal cell-surface autoantibodies

Michael Gilligan, Luke O’Donnell, Andrew Westbrook, Niall Tubridy et autres

ie, gb (code pays fourni par la source)

Neuroinflammatory activation in sensory and motor regions of the cortex is related to sensorimotor function in individuals with low back pain maintained by nociplastic mechanisms: A preliminary proof‐of‐concept study

Muath A. Shraim, Hugo Massé‐Alarie, Michael J. Farrell, Rocco Cavaleri et autres

BACKGROUND: Chronic pain involves communication between neural and immune systems. Recent data suggest localization of glial (brain immune cells) activation to the sensorimotor regions of the brain cortex (S1/M1) in chronic low back pain (LBP). As glia perform diverse functions that impact …

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