Michael Gilligan

Calmodulin Kinase-like Vesicle-associated Protein (CAMKV) Autoimmune Encephalitis: Neurological & Oncological Accompaniments, Treatments, & Outcomes (S30.005)

Diana Anissian, Michael Gilligan, Alise Carlson, Christopher Hogge et autres

To describe the clinical features of calmodulin kinase-like vesicle-associated protein (CAMKV)-IgG associated autoimmune paraneoplastic encephalitis.

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Novel methods for neural IgG characterization and validation in autoimmune neurologic disorders

Michael Gilligan, Andrew McKeon

Neural autoantibody testing is standard for patients with suspected autoimmune neurologic disorders. The number of neural antibodies has increased dramatically in the past 40 years, with over 50 disease-specific neural antibodies defined to date. The advent of immune-profiling assays such as protein …

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Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Michael Gilligan, John R. Mills, Naveen Kumar Paramasivan, Connie E. Lesnick et autres

OBJECTIVE: We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay-observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP-Seq). METHODS: Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled; …

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DAGLA autoantibody experience at Mayo Clinic

Nisa Vorasoot, Cigdem Isitan-Alkawadri, Bharat Pillai, Ramona Miske et autres

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‘Amphiphysin-like’ IgGs Targeting Novel Synaptic Vesicle Trafficking Autoantigens (P1-8.002)

Michael Gilligan, John R. Mills, Naveen Kumar Paramasivan, Connie E. Lesnick et autres

To report 4 novel autoantibodies (resembling amphiphysin-IgG on murine brain tissue immunofluorescence assay [TIFA]) targeting antigens critical to neural synaptic vesicular trafficking.

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Exploring autoantigens in autoimmune limbic encephalitis using phage immunoprecipitation sequencing

Haidara Kherbek, Naveen Kumar Paramasivan, Surendra Dasari, Carley Karsten et autres

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Autoimmune encephalitis: recovery, residual symptoms and predictors of long-term sequelae

Smathorn Thakolwiboon, Michael Gilligan, Emma Orozco, Jeffrey W. Britton et autres

BACKGROUND: Data regarding long-term recovery from autoimmune encephalitis (AE) remain limited. METHODS: This retrospective observational study investigated outcomes in 182 patients who met the 2016 criteria for definite AE. Recovery data were available in 172 patients. Follow-up data at ≥24 months post-attack …

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Autoimmune brainstem encephalitis: Clinical associations, outcomes, and proposed diagnostic criteria

Michael Gilligan, Smathorn Thakolwiboon, Emma Orozco, Samantha A. Banks et autres

OBJECTIVE: We describe neurologic phenotype, clinical associations, and outcomes in autoimmune brainstem encephalitis. METHODS: Medical records of neural-IgG positive autoimmune brainstem encephalitis patients diagnosed at Mayo Clinic (January 1, 2006-December 31, 2022) were reviewed. RESULTS: Ninety-eight patients (57 male) were included. Median …

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A complex and severe encephalitis associated with four co-existing neuronal cell-surface autoantibodies

Michael Gilligan, Luke O’Donnell, Andrew Westbrook, Niall Tubridy et autres

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Autoimmune Neurobeachin Cerebellar Ataxia

Eati Basal, Michael Gilligan, Connie E. Lesnick, Andrew McKeon

BACKGROUND: There are more than 30 immunoglobulin G (IgG) autoantibody biomarkers of autoimmune cerebellar ataxia reported. OBJECTIVE: To describe a novel IgG biomarker targeting neurobeachin, a scaffolding protein integral to synapse formation and function. METHODS: Clinical and laboratory-based assessment was used for …

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Paraneoplastic Calmodulin Kinase‐Like Vesicle‐Associated Protein ( CAMKV ) Autoimmune Encephalitis

Michael Gilligan, Connie E. Lesnick, Yong Guo, Michael Bradshaw et autres

OBJECTIVES: To report an autoimmune paraneoplastic encephalitis characterized by immunoglobulin G (IgG) antibody targeting synaptic protein calmodulin kinase-like vesicle-associated (CAMKV). METHODS: Serum and cerebrospinal fluid (CSF) samples harboring unclassified antibodies on murine brain-based indirect immunofluorescence assay (IFA) were screened by human protein …

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Residual Symptoms, Recovery & Predictors of Long-term Sequalae After Autoimmune Encephalitis (S4.003)

Smathorn Thakolwiboon, Emma Orozco, Michael Gilligan, Jeffrey W. Britton et autres

To investigate residual symptoms, recovery, and long-term sequelae in autoimmune encephalitis (AE).

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