Kek Heng Chua

Hepatitis E virus seroepidemiology among Malaysian blood donors: Prevalence and associated risk factors

Christina Lai Ling Lee, Li Ping Wong, Lee Lee Lai, Boon Pin Kee et autres

BACKGROUND AND OBJECTIVES: Hepatitis E virus (HEV) is a recognized transfusion-transmissible pathogen with significant impact in immunocompromised recipients. Data from Southeast Asia are limited, and the epidemiology of HEV in Muslim-majority populations with low pork consumption remains poorly characterized. This study aimed …

my, cn, kr (code pays fourni par la source)

Colorimetric LAMP detection of Group B Streptococcus in aquaculture via the ccpA gene

Suat Moi Puah, Wei Ching Khor, Yen Ching Lim, Kyaw Thu Aung et autres

Comparative transcriptomics uncover differential regulatory mechanisms in MRSA and MSSA biofilms through RNA-sequencing

Sherry Usun Jones, Boon Pin Kee, Ching Hoong Chew, Chew Chieng Yeo et autres

Staphylococcus aureus is an opportunistic pathogen that can form biofilms and is known for its persistence in causing infections. This study aims to characterise the transcriptional mechanisms underlying biofilm formation in both methicillin-resistant (MRSA) and methicillin-susceptible (MSSA) strains. Total RNA was extracted …

my (code pays fourni par la source)

Gut Microbiota-Derived Metabolite and Heart Failure with Reduced Ejection Fraction (HFrEF): Elevated Trimethylamine N-Oxide (TMAO) as a Potential Biomarker

Sheh Wen Kuan, Wei Leik Ng, A. Loch, Kek Heng Chua et autres

Gut-derived metabolites, particularly trimethylamine N-oxide (TMAO), have been implicated in the pathophysiology of heart failure (HF). This study investigated the associations between TMAO, cardiac function, and clinical parameters to evaluate TMAO’s potential as a biomarker for heart failure with reduced ejection fraction …

my (code pays fourni par la source)

Antiproliferative effects of dihydrotanshinone I on autosomal dominant polycystic kidney disease via immunomodulation

Rhubaniya Mahendran, Soo Kun Lim, Kien Chai Ong, Kek Heng Chua et autres

my (code pays fourni par la source)

Autophagy protein 5 (ATG5) rs573775 protects Malaysian Malay women from systemic lupus erythematosus

Hwa Chia Chai, Kek Heng Chua

my (code pays fourni par la source)

Development of a Visual Loop‐Mediated Isothermal Amplification Assay for Rapid Detection of Morganella morganii

Kek Heng Chua, Tien‐Tien Vicky Lau, Suat Moi Puah

ABSTRACT Morganella morganii is a Gram‐negative bacterium associated with foodborne diseases and histamine toxicity in fish, posing significant public health concerns. Traditional detection methods, such as polymerase chain reaction (PCR), often require costly equipment, restricting their applicability in resource‐limited environments. In this …

my (code pays fourni par la source)

Bacterial Community Composition and Prevalence of Aeromonas dhakensis in Four Tilapia Freshwater Aquaculture Systems in Malaysia

Sook Ling Lim, Suat Moi Puah, Siti Nursyuhada Baharudin, Nur Insyirah Mohd Razalan et autres

The tilapia (Oreochromis) aquaculture industry in Malaysia has expanded rapidly to meet the increasing demand for animal protein. However, this growth is challenged by microbial infections, particularly those caused by the emerging pathogen Aeromonas dhakensis. This study aimed to investigate the microbial …

my, sg (code pays fourni par la source)

Development of a colorimetric loop-mediated isothermal amplification (cLAMP) assay for the rapid and visual detection of Aeromonas dhakensis infection in aquaculture

Suat Moi Puah, Wei Ching Khor, Yen Ching Lim, Kyaw Thu Aung et autres

my, sg (code pays fourni par la source)

Rapid Detection of Aeromonas veronii Using GGDEF Gene‐Based Colorimetric Loop‐Mediated Isothermal Amplification

Tien Tien Vicky Lau, Suat Moi Puah, Kek Heng Chua

ABSTRACT Aeromonas veronii has emerged as an important fish pathogen that poses threats to the aquaculture industry worldwide, and rapid detection is essential to minimise negative economic impact. In this study, a colorimetric loop‐mediated isothermal amplification (LAMP) assay was developed to rapidly …

my (code pays fourni par la source)

Sanguinoderma rugosum (Agaricomycetes), a Wild Malaysian Medicinal Mushroom, Triggers Anti-Neuroinflammatory Genes Expression in LPS-Stimulated BV-2 Microglial Cells

Pui-Mun Chan, Yee Shin Tan, Kek Heng Chua, Vikineswary Sabaratnam et autres

Sanguinoderma rugosum (synonym: Amauroderma rugosum) is a wild medicinal mushroom reported to prevent epileptic episodes and constant crying in babies within indigenous communities in Malaysia. It also has potential applications in the management of oxidative-related diseases. The aim of this study was …

my (code pays fourni par la source)

Differential expression of small RNAs in biofilm-producing clinical methicillin-susceptible Staphylococcus aureus recovered from human urine

Sherry Usun Jones, Boon Pin Kee, Ching Hoong Chew, Chew Chieng Yeo et autres

-acting using CopraRNA analysis. Therefore, both sRNAs merit further investigations via reverse genetic approaches to elucidate their mechanism of translational regulation. In summary, the transcriptomic analysis conducted in this study offers new insights into the potential regulatory roles of sRNAs in MSSA …

my (code pays fourni par la source)