Hepatitis E virus seroepidemiology among Malaysian blood donors: Prevalence and associated risk factors
Rattachement africain : my, cn, kr. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND AND OBJECTIVES: Hepatitis E virus (HEV) is a recognized transfusion-transmissible pathogen with significant impact in immunocompromised recipients. Data from Southeast Asia are limited, and the epidemiology of HEV in Muslim-majority populations with low pork consumption remains poorly characterized. This study aimed to determine anti-HEV immunoglobulin G (IgG) and immunoglobulin M (IgM) seroprevalence and associated demographic, dietary, environmental, zoonotic and knowledge-related factors among Malaysian blood donors. MATERIALS AND METHODS: A prospective cross-sectional study was conducted among 500 consecutive blood donors at the Universiti Malaya Medical Centre. Anti-HEV IgG and IgM were measured using enzyme-linked immunosorbent assay. A structured questionnaire assessed demographic, dietary, environmental and zoonotic exposures. Univariate and multivariable logistic regression identified predictors of anti-HEV IgG seropositivity. RESULTS: Anti-HEV IgG seroprevalence was 2.8% (14/500), and IgM positivity was 0.6% (3/500). IgG seropositivity increased with age but showed no association with dietary exposures, including pork consumption. Knowledge of HEV was low, with a median score of 1 out of 12. Multivariable analysis identified freshwater recreational exposure (adjusted odds ratio [aOR] 20.04; p = 0.017) and direct rodent contact (aOR 13.36; p = 0.030) as factors associated with anti-HEV IgG seropositivity; however, these findings were based on small numbers of exposed individuals and should be interpreted cautiously. CONCLUSION: HEV seroprevalence in Malaysian blood donors was low, indicating a limited burden of previous HEV infection. The observed epidemiological profile suggests that environmental and zoonotic exposures may be associated with HEV seropositivity, although these findings require cautious interpretation. These findings provide baseline data for continued surveillance and future evaluation of transfusion-transmitted HEV risk in Malaysia.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Hepatitis <scp>E</scp> virus seroepidemiology among Malaysian blood donors: Prevalence and associated risk factors
- Date Crossref
- 18/08/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University Malaya Medical Centre pays non établi dans la noticeÉtablissement de santé
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University of Malaya pays non établi dans la noticeUniversité ou école supérieure
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Fujian Medical University Department of Epidemiology and Health Statistics pays non établi dans la noticeUniversité ou école supérieure
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Korea University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Universiti Sains Malaysia pays non établi dans la noticeUniversité ou école supérieure
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Xiamen University State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics pays non établi dans la noticeUniversité ou école supérieure
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State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics pays non établi dans la noticeStructure de recherche
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Chongqing Medical University pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Universiti Malaya Kuala Lumpur Malaysia Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Department of Transfusion Medicine Universiti Malaya Medical Centre Kuala Lumpur Malaysia pays non établi dans la noticeInstitution
University Malaya Medical Centre, University of Malaya et Department of Epidemiology and Health Statistics — Fujian Medical University, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.