Anand Ramaian Santhaseela

Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

Anna Rodina, Chao Xu, Chander Singh Digwal, Suhasini Joshi et autres

Systems-level assessments of protein-protein interaction (PPI) network dysfunctions are currently out-of-reach because approaches enabling proteome-wide identification, analysis, and modulation of context-specific PPI changes in native (unengineered) cells and tissues are lacking. Herein, we take advantage of chemical binders of maladaptive scaffolding structures …

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Use of Native-PAGE for the Identification of Epichaperomes in Cell Lines

Tanaya Roychowdhury, Anand Ramaian Santhaseela, Sahil Sharma, Palak Panchal et autres

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Altered Lysosomal Function Manipulates Cellular Biosynthetic Capacity By Remodeling Intracellular Cholesterol Distribution

Sudarshana Rajasekaran, Anand Ramaian Santhaseela, Shamila Ragunathan, Sangita Venkataraman et autres

in (code pays fourni par la source)

Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein–Protein Interaction Networks

Chander Singh Digwal, Sahil Sharma, Anand Ramaian Santhaseela, Stephen D. Ginsberg et autres

Alterations in proteostasis are known contributors to various maladies including cancer and neurodegenerative disorders. Here, we discuss how chemical biology has brought to proteostasis an appreciation that goes beyond biogenesis, folding, trafficking, and degradation of proteins, to incorporate the study of the …

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Does mTORC1 inhibit autophagy at dual stages?

Anand Ramaian Santhaseela, Tamilselvan Jayavelu

Extensive studies have attributed the lysosomal localization of the mechanistic target of rapamycin complex 1 (mTORC1) during its activation. However, the exact biological significance of this lysosomal localization of mTORC1 remains ill-defined. Interestingly, findings have shown that localization of the lysosome itself …

in (code pays fourni par la source)

Astroglial biotin deprivation under endoplasmic reticulum stress uncouples BCAA‐mTORC1 role in lipid synthesis to prolong autophagy inhibition in the aging brain

Dhasarathan Ganesan, Anand Ramaian Santhaseela, Sudarshana Rajasekaran, Senthilraja Selvam et autres

Autophagy delays the onset of endoplasmic reticulum (ER) stress by recycling cellular debris. However, the cues that elicit autophagy under the emergence of ER stress and their dysregulation during aging remains obscure. Amino acids, notably branched-chain amino acids (BCAA), get accumulated in …

in (code pays fourni par la source)

Autophagy inhibition by biotin elicits endoplasmic reticulum stress to differentially regulate adipocyte lipid and protein synthesis

Senthilraja Selvam, Anand Ramaian Santhaseela, Dhasarathan Ganesan, Sudarshana Rajasekaran et autres

Biotin is an indispensable adipogenic agent, and its ability to coordinate carbohydrate, lipid, and amino acid metabolism sensitizes insulin signaling in adipocytes. This enables the organism to adapt and survive under nutrient stress by synthesis and storage of lipids. Biotin deficiency mimics …

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