Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein–Protein Interaction Networks
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Le résumé fourni par la source
Alterations in proteostasis are known contributors to various maladies including cancer and neurodegenerative disorders. Here, we discuss how chemical biology has brought to proteostasis an appreciation that goes beyond biogenesis, folding, trafficking, and degradation of proteins, to incorporate the study of the interaction fate of proteins, especially as they occur in disease processes at the proteome-wide level. This has been enabled by the discovery of epichaperomes, long-lived assemblies, and disease-associated pathologic scaffolds composed of tightly bound chaperones, co-chaperones, and other factors, and catalyzed by generation and implementation of several chemical probes, from epichaperome disrupters to epichaperome affinity-purification tools and epichaperome detection and quantitation probes. We highlight the knowledge gained to date through chemical biology on the deleterious effect epichaperomes have on reshaping protein–protein interaction networks (i.e. interactomes) at a proteome-wide level in disease, especially in cancer and neurodegenerative diseases. We also discuss the restorative effects of epichaperome disrupters through rebalancing proteome-wide interactome defects. Lastly, we highlight how through the use of chemical probes to enable epichaperome detection and quantitation, the discipline of chemical biology has provided opportunities for precision medicine.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Epichaperomes as a Gateway to Understanding, Diagnosing, and Treating Disease Through Rebalancing Protein–Protein Interaction Networks
- Date Crossref
- 14/11/2022
- Éditeur
- Wiley
- Type
- other
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Memorial Sloan Kettering Cancer Center Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Nathan Kline Institute for Psychiatric Research Center for Dementia Research pays non établi dans la noticeOrganisation à but non lucratif
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New York University Departments of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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Cornell University pays non établi dans la noticeUniversité ou école supérieure
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Program in Chemical Biology Program pays non établi dans la noticeInstitution
Department of Medicine — Memorial Sloan Kettering Cancer Center, Center for Dementia Research — Nathan Kline Institute for Psychiatric Research et Departments of Psychiatry — New York University, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.