Dustin L. Heiden

Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection

Jennifer N. Berger, Dustin L. Heiden, Brendan Monogue, John David Beckham et autres

The central nervous system (CNS) includes a uniquely regulated immune response that supports homeostasis, response to injury, and response to pathogens. Recent work has shown that virus-associated immune responses in the CNS may contribute to neuronal injury and long-term outcomes such as …

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Antiviral innate immunity induces alpha synuclein phosphorylation at serine129 in neurons independent of aggregation

Dustin L. Heiden, Camille Merrick, Robert C. Evans, Alexander J. Rajic et autres

Alpha synuclein (asyn) is expressed in neurons and is associated with the pathogenesis of synucleinopathies like Parkinson's Disease. Asyn aggregates are associated with phosphorylation at serine position 129 (pS129), which can be induced by environmental triggers, including viral infection, and the risk …

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A double-edged sword: bystander CD8+ T cells cause collateral damage in the brain during infection 3922

Jennifer N. Berger, Dustin L. Heiden, Brendan Monogue, Jared S. Klarquist et autres

Abstract Description We investigated CNS-infiltrating T cells during infection with the attenuated Venezuelan equine encephalitis virus vaccine strain TC83 (TC83), which replicates to high viral titers in the brain of wild-type mice without lethality. Thus, we could study the immune response throughout …

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Identifying antigen-presenters in the islets during type 1 diabetes 3716

Lena M. Cedrone, Sarah C. Stischer, Jennifer C. Whitesell, Robin S. Lindsay et autres

Abstract Description Type 1 diabetes (T1D) is an autoimmune disorder where islet antigen-specific T cells destroy insulin-producing beta cells. While the role of T cells in T1D is well understood, the contribution of myeloid cells remains less clear. Our analyses show that …

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Anti-viral immunity induces pS129 alpha synuclein expression independent of alpha synuclein aggregation 4176

Dustin L. Heiden, Robert C. Evans, Camille Merrick, Jennifer N. Berger et autres

Abstract Description Parkinson’s Disease (PD) affects over 10 million people globally, with its prevalence increasing. A hallmark of PD is the aggregation of phosphorylated alpha-synuclein (pS129-Asyn), which is associated with beta-sheet structures. Alpha-synuclein (Asyn), a 140-amino acid protein expressed in neurons, is …

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Bystander CD8+ T cells are Important Antiviral Effectors in the Brain

Jennifer N. Berger, Brendan Monogue, Dustin L. Heiden, Jared S. Klarquist et autres

Abstract The central nervous system (CNS) presents a unique immunological environment with restricted infiltration of immune cells from the periphery. Since much is unknown about CNS-infiltrating immune cells during infection, we utilized the attenuated Venezuelan equine encephalitis virus vaccine strain TC83 (VEEV-TC83) …

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A functional role for alpha-synuclein in neuroimmune responses

Dustin L. Heiden, Brendan Monogue, Muhammad Ali, John David Beckham

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Autoimmunity in motion: Mechanisms of immune regulation and destruction revealed by in vivo imaging*

Jordan Jacobelli, Alan E. Buser, Dustin L. Heiden, Rachel Sharon Friedman

Autoimmunity arises when mechanisms of immune tolerance fail. Here we discuss mechanisms of T cell activation and tolerance and the dynamics of the autoimmune response at the site of disease. Live imaging of autoimmunity provides the ability to analyze immune cell dynamics …

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Combinatorial liposomal peptide vaccine induces IgA and confers protection against influenza virus and bacterial super‐infection

Mehfuz Zaman, Victor C. Huber, Dustin L. Heiden, Katerina N DeHaan et autres

Abstract Objectives The upper respiratory tract is the major entry site for Streptococcus pyogenes and influenza virus. Vaccine strategies that activate mucosal immunity could significantly reduce morbidity and mortality because of these pathogens. The severity of influenza is significantly greater if a …

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A chimeric influenza hemagglutinin delivered by parainfluenza virus 5 vector induces broadly protective immunity against genetically divergent influenza a H1 viruses in swine

Zhuo Ya Li, Sarah Zaiser, Pengcheng Shang, Dustin L. Heiden et autres

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Evaluation of Self-Adjuvanting M2e Vaccine Efficacy in Response to Influenza A Virus Challenge

Dustin L. Heiden