John David Beckham

Myeloid cell IL-15 production in the brain supports bystander CD8+ T cell neuropathic immune responses following virus infection

Jennifer N. Berger, Dustin L. Heiden, Brendan Monogue, John David Beckham et autres

The central nervous system (CNS) includes a uniquely regulated immune response that supports homeostasis, response to injury, and response to pathogens. Recent work has shown that virus-associated immune responses in the CNS may contribute to neuronal injury and long-term outcomes such as …

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Reviews of "Autoantibodies Neutralizing Type I IFNs in 40% of Patients with WNV Encephalitis in Seven New Cohorts"

John David Beckham, Jennifer Berger, Benedikt Strunz

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Review 1: "Autoantibodies Neutralizing Type I IFNs in 40% of Patients with WNV Encephalitis in Seven New Cohorts"

John David Beckham, Jennifer Berger

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A double-edged sword: bystander CD8+ T cells cause collateral damage in the brain during infection 3922

Jennifer N. Berger, Dustin L. Heiden, Brendan Monogue, Jared S. Klarquist et autres

Abstract Description We investigated CNS-infiltrating T cells during infection with the attenuated Venezuelan equine encephalitis virus vaccine strain TC83 (TC83), which replicates to high viral titers in the brain of wild-type mice without lethality. Thus, we could study the immune response throughout …

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Anti-viral immunity induces pS129 alpha synuclein expression independent of alpha synuclein aggregation 4176

Dustin L. Heiden, Robert C. Evans, Camille Merrick, Jennifer N. Berger et autres

Abstract Description Parkinson’s Disease (PD) affects over 10 million people globally, with its prevalence increasing. A hallmark of PD is the aggregation of phosphorylated alpha-synuclein (pS129-Asyn), which is associated with beta-sheet structures. Alpha-synuclein (Asyn), a 140-amino acid protein expressed in neurons, is …

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Leptin and melanocortin signalling in the response to infection

Roger R. Fan, John David Beckham, Kuppuswamy Rajagopalan

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Oropouche Virus: An Emerging Neuroinvasive Arbovirus

Daniel M. Pastula, John David Beckham, Kenneth L. Tyler

Oropouche virus (OROV) is an arthropod-borne virus (arbovirus) in the Orthobunyavirus genus and Peribunyaviridae viral family that is endemic to parts of South America, Central America, and the Caribbean. It has recently emerged in Cuba, and travel-imported cases are recently being reported …

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Brain Abscesses in the Tropics

Michaele Francesco Corbisiero, R. Ripperton, Elizabeth Garcia‐Creighton, Anthony M. Smyth et autres

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Activation and pro-inflammatory cytokine production by unswitched memory B cells during SARS-CoV-2 infection

Moriah J. Castleman, Adriana Luna Santos, Kelsey E. Lesteberg, James P. Maloney et autres

Memory B cells are comprised of unswitched (CD27+IgD+) and switched (CD27+IgD-) subsets. The origin and function of unswitched human memory B cells are debated in the literature, whereas switched memory B cells are primed to respond to recurrent infection. Unswitched memory B …

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Zika virus dumbbell-1 structure is critical for sfRNA presence and cytopathic effect during infection

Monica E. Graham, Camille Merrick, Benjamin M. Akiyama, Matthew J. Szucs et autres

ABSTRACT All flaviviruses contain conserved RNA structures in the 3′ untranslated region (3′ UTR) that are important for flavivirus RNA replication, translation, and pathogenesis. Flaviviruses like Zika virus (ZIKV) contain multiple conserved RNA structures in the viral 3′ UTR, including the structure …

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Bystander CD8+ T cells are Important Antiviral Effectors in the Brain

Jennifer N. Berger, Brendan Monogue, Dustin L. Heiden, Jared S. Klarquist et autres

Abstract The central nervous system (CNS) presents a unique immunological environment with restricted infiltration of immune cells from the periphery. Since much is unknown about CNS-infiltrating immune cells during infection, we utilized the attenuated Venezuelan equine encephalitis virus vaccine strain TC83 (VEEV-TC83) …

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Phenotypical and Functional Characterization of Unswitched Memory B cells verses Switched during SARS-CoV-2 Infection

Moriah J. Castleman, Adriana Luna Santos, Kelsey E. Lesteberg, James P. Maloney et autres

Abstract Memory B cells are comprised of unswitched (CD27+IgD+) and switched (CD27+IgD-) subsets. The origin and function of unswitched human memory B cells remains controversial, whereas switched memory B cells are primed to respond to recurrent infection. Unswitched memory B cells were …

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