Daniel Wayne Armstrong

Revisiting Solvent Impurities with Log-Based Fluorescence Detection and GC–MS

Maria Olds, Siddharth Jaya Sajeevan J, Alain Berthod, Daniel Wayne Armstrong

Solvents are needed in all branches of chemistry, and they must be eliminated after use. Impurities present in these solvents could concentrate detrimentally during chemical and, especially, pharmaceutical processes. So it is critically important to know the purity of the solvents used. …

us, fr (code pays fourni par la source)

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun et autres

ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium …

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Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun et autres

Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4-dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel …

Kinetic investigation on d-amino acid containing peptides and carboxypeptidase Y

Joshua I. Putman, Arzoo M. Patel, Maria Olds, Alaa Aziz et autres

us (code pays fourni par la source)

Synthesis and Isomerization of Tetrahydro-4 H -chromene Derivatives

Ryan Jacob Burk, Anasuya Ghorai, James X. Mao, Vo Quang Huy Phan et autres

One-pot multicomponent reactions (MCRs) are commonly used to synthesize heterocyclic compounds including tetrahydro-4 H -chromene derivatives. Despite extensive research on 4 H -chromene synthesis via MCR, the formation and characterization of structural isomers arising from diketones that lack a vertical plane of …

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Back to basic: Using ammonium hydroxide to improve peptide epimer/isomer liquid chromatography separations

Umang Dhaubhadel, Arzoo M. Patel, Daniel Wayne Armstrong

us (code pays fourni par la source)

Discovery of novel 1H-pyrazolo[3,4-d]pyrimidine derivatives as BRK/PTK6 inhibitors

Baku Acharya, Maha Hanafi, Luke Enemark, Daniel Wayne Armstrong et autres

us (code pays fourni par la source)

Selective Chemometric Elimination of Co-Eluting Components in Chiral and Achiral Liquid Chromatographic Analyses

Siddharth Jaya Sajeevan J, M. Farooq Wahab, Daniel Wayne Armstrong

No stationary phase can address all separation problems, as such a capability is both statistically and thermodynamically implausible. Overlapping peaks in complex mixtures are unavoidable for any given eluent and stationary phase combination. Since UV spectra are broad, it is not possible …

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Simulating scatter in fragmentation of metal rings and tubes

J.D. Robson, Daniel Wayne Armstrong, Joseph Cordell

Understanding the break up of a metal component under high strain rate deformation by natural fragmentation is important in a range of industrial and military applications. In this work, natural fragmentation of metal rings and tubes has been simulated in a finite …

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Carbonate esters as green alternatives in chromatographic separations

Alain Berthod, Daniel Wayne Armstrong

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On the use of ethylene carbonate as a green solvent in mobile phases

Alain Berthod, Daniel Wayne Armstrong

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An updated patent review of rearranged during transfection (RET) kinase inhibitors (2022-present)

Daniel Wayne Armstrong, Maha Hanafi, Brendan Frett

INTRODUCTION: Rearranged during transfection (RET) is a receptor tyrosine kinase essential for cell signaling processes such as proliferation, differentiation, and migration. RET alterations, including point mutations and gene fusions, contribute to oncogenesis. Recent advances in precision oncology have led to the development …

us, Égypte (code pays fourni par la source)