Marek Winiarski

Changes of serum cell adhesion molecules as potential markers of inflammation severity, metabolic status and mortality in patients infected with COVID-19.

Iwona Popiołek, Dominika Stygar, Barbara Wizner, Marek Sanak et autres

Acute-phase viral infections, such as COVID-19, trigger a complex interplay of proinflammatory and regulatory responses, influencing both tissue repair and damage. Intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and platelet endothelial cell adhesion molecule-1 (PECAM-1) play crucial roles in immune …

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Concordance of the rapid urease test and the histopathology report in detecting Helicobacter pylori infection in a bariatric population. A retrospective cohort study

Piotr Panek, Justyna Rymarowicz, Miłosz Czeliński, Jakub Pośpiech et autres

Introduction: Bariatric surgery has become one of the most prominent treatment modalities for obesity.Esophagogastroscopy (EGD) with Helicobacter pylori testing is a part of the preoperative work-up.There are no guidelines defining the preferred method of detecting H. pylori.Aim: The study aimed to establish …

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Development of selective ssDNA micro-probe for PD1 detection as a novel strategy for cancer imaging

Stanisłąw Malicki, Anna Czarna, Edyta Żyła, Barbara Pucelik et autres

Programmed death receptor 1, PD1, modulates the function of immune cells by providing inhibitory signals and constitutes the marker of immune exhaustion. Monitoring the level of PD1 promises a useful diagnostic approach in autoimmune diseases and cancer. Here we describe the development …

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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Stephen R Knight, Catherine A. Shaw, Riinu Pius, Thomas M Drake et autres

BACKGROUND: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between …

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Predictive Role of Admission Venous Lactate Level in Patients with Upper Gastrointestinal Bleeding: A Prospective Observational Study

Marcin Strzałka, Marek Winiarski, Marcin Dembiński, Michał Pędziwiatr et autres

Upper gastrointestinal bleeding (UGIB) is one of the most common emergencies. Risk stratification is essential in patients with this potentially life-threatening condition. The aim of this prospective study was to evaluate the usefulness of the admission venous lactate level in predicting clinical …

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Anti-inflammatory adipokines: chemerin, vaspin, omentin concentrations and SARS-CoV-2 outcomes

Michał Kukla, Tomasz Menżyk, Marcin Dembiński, Marek Winiarski et autres

Coronavirus disease 2019 (COVID-19) is associated with systemic inflammation. A wide range of adipokines activities suggests they influence pathogenesis and infection course. The aim was to assess concentrations of chemerin, omentin, and vaspin among COVID-19 patients with an emphasis on adipokines relationship …

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Fetuin-A Deficiency but Not Pentraxin 3, FGF-21, or Irisin, Predisposes to More Serious COVID-19 Course

Michał Kukla, Tomasz Menżyk, Marcin Dembiński, Marek Winiarski et autres

Analysis of liver biopsy specimens showed that SARS-CoV-2 might have led to liver damage. This study aimed to evaluate the role of selected hepatokines and myokines in the development and progression of COVID-19. Seventy patients with laboratory-confirmed COVID-19 and 20 healthy volunteers …

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Diagnostic Significance of Serum Galectin-3 in Hospitalized Patients with COVID-19—A Preliminary Study

Beata Kuśnierz‐Cabala, Barbara Maziarz, Paulina Dumnicka, Marcin Dembiński et autres

Severe coronavirus disease 2019 (COVID-19) is associated with hyperinflammation leading to organ injury, including respiratory failure. Galectin-3 was implicated in innate immunological response to infections and in chronic fibrosis. The aim of our preliminary study was the assessment of the diagnostic utility …

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Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

Stephen R Knight, Caitlin Shaw, Riinu Pius, Thomas M Drake et autres

BACKGROUND: 80% of individuals with cancer will require a surgical procedure, yet little comparative data exist on early outcomes in low-income and middle-income countries (LMICs). We compared postoperative outcomes in breast, colorectal, and gastric cancer surgery in hospitals worldwide, focusing on the …

Integrative genomics reveal a role for MCPIP1 in adipogenesis and adipocyte metabolism

Magdalena Łośko, Dobrochna Dolicka, Natalia Pydyn, Urszula Jankowska et autres

Abstract Obesity is considered a serious chronic disease, associated with an increased risk of developing cardiovascular diseases, non-alcoholic fatty liver disease and type 2 diabetes. Monocyte chemoattractant protein-1-induced protein-1 (MCPIP1) is an RNase decreasing stability of transcripts coding for inflammation-related proteins. In …

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Business Risk and Project Management in Civil Construction Branch

Marek Winiarski, Mariusz Urbański, Riffat Faizan

Abstract Project management is general planning, coordination and inspection of the project, from the initial stage all the way to final phase, its purpose is an accomplishment of the accepted task and creation of the functional final effect, without exceeding established costs, …

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Business Risk and Project Management in Civil Construction Branch

Marek Winiarski, Mariusz Urbański, Riffat Faizan

The magazine's publications deal with issues related to work safety. Both in the area of occupational health and safety, organization of the workplace (technical aspects) and the environment (environmental factors in working conditions). The publications presented combine legal requirements in the field …