Edyta Żyła

Development of selective ssDNA micro-probe for PD1 detection as a novel strategy for cancer imaging

Stanisłąw Malicki, Anna Czarna, Edyta Żyła, Barbara Pucelik et autres

Programmed death receptor 1, PD1, modulates the function of immune cells by providing inhibitory signals and constitutes the marker of immune exhaustion. Monitoring the level of PD1 promises a useful diagnostic approach in autoimmune diseases and cancer. Here we describe the development …

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Imaging of Clear Cell Renal Carcinoma with Immune Checkpoint Targeting Aptamer-Based Probe

Stanisłąw Malicki, Barbara Pucelik, Edyta Żyła, Małgorzata Benedyk‐Machaczka et autres

Immune checkpoint targeting immunotherapy has revolutionized the treatment of certain cancers in the recent years. Determination of the status of immune checkpoint expression in particular cancers may assist decision making. Here, we describe the development of a single-stranded aptamer-based molecular probe specifically …

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Structural Characterization of a Macrocyclic Peptide Modulator of the PD-1/PD-L1 Immune Checkpoint Axis

Edyta Żyła, Bogdan Musielak, Tad A. Holak, Grzegorz Dubin

The clinical success of PD-1/PD-L1 immune checkpoint targeting antibodies in cancer is followed by efforts to develop small molecule inhibitors with better penetration into solid tumors and more favorable pharmacokinetics. Here we report the crystal structure of a macrocyclic peptide inhibitor (peptide …

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Structural characteristics of macrocyclic peptide as a potent modulator of PD‐1/PD‐L1 immune checkpoint axis

Edyta Żyła, Grzegorz Dubin

Blocking therapy targeted towards the immune checkpoint PD‐1/PD‐L1 pathway has proven to be a very effective approach for treatment of a number of tumor types and has become an important tool in immunotherapy harnessing therapeutic antibodies. Although successful, these applications face several …

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Candida albicans Shields the Periodontal Killer Porphyromonas gingivalis from Recognition by the Host Immune System and Supports the Bacterial Infection of Gingival Tissue

Dominika Bartnicka, Miriam Gonzalez‐Gonzalez, Joanna Sykut, Joanna Kozieł et autres

Candida albicans is a pathogenic fungus capable of switching its morphology between yeast-like cells and filamentous hyphae and can associate with bacteria to form mixed biofilms resistant to antibiotics. In these structures, the fungal milieu can play a protective function for bacteria …

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Finansowanie terroryzmu w państwach Unii Europejskiej

Edyta Żyła

Zagrożenie atakami terrorystycznymi w Europie Zachodniej skłoniło społeczność międzynarodową do zintensyfikowania działań mających na celu walkę z terroryzmem. Ich ważnym elementem stało się przeciwdziałanie finansowaniu terroryzmu oraz jego zwalczanie. Główną rolę w tym procesie odgrywa Grupa Specjalna do spraw Przeciwdziałania Praniu Pieniędzy …

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Powrót do Ojczyzny? Patriotyzm wobec nowych czasów. Kontynuacje i nawiązania [Return to Homeland? Patriotism in the face of the new times. Continuations and references], ed. Cezary Smuniewski, Paweł Sporek, Instytut Nauki o Polityce, Warszawa 2017, pp. 438

Edyta Żyła

Edyta Żyła Powrót do Ojczyzny? Patriotyzm wobec nowych czasów. Kontynuacje i nawiązania [Return to Homeland? Patriotism in the face of the new times. Continuations and references], ed. Cezary Smuniewski, Paweł Sporek, Instytut Nauki o Polityce, Warszawa 2017, pp. 438 [View PDF] DOI: …

The system of counteracting and combating terrorist financing in Poland in view of the existing threats

Edyta Żyła

The article includes issues related to counteracting and combating terrorist financing in Poland in the context of existing threats. The regulations in force on the international level, and provisions governing these issues in the Polish legal system are both discussed. Based on …

The Mechanism of Type I Interferon-Mediated Polarization of Tumor-Associated Neutrophils in Mice and Human

Lisa Andzinski, Mozhgan Dehghan Harati, Edyta Żyła, Nadine Kasnitz et autres

Abstract Neutrophils are the most abundant cells of all white blood cells and play a key role in host inflammatory responses. Importantly, inflammation has been associated with increased susceptibility for cancer and neutrophils, as a crucial component of this process, play essential …

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Characterization of selected immune checkpoint inhibitors

Edyta Żyła

Berecie za opiekę merytoryczną, cenne uwagi i sugestie oraz życzliwość.