2026
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OpenAlex
Konstantinos Chiotis, Charles Windon, B.V. Siegel, Charles Apgar et autres
Amyloid-targeting therapies and growing reimbursement are expected to increase the clinical use of amyloid PET. The Imaging Dementia—Evidence for Amyloid Scanning (IDEAS) study captured more than 18,000 clinical scan interpretations from local radiologists and nuclear medicine physicians in the United States. This …
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2026
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OpenAlex
Mark A. Dubbelman, Tanisha G. Hill‐Jarrett, Silvia Chapman, Gustavo Alves Andrade dos Santos et autres
Subjective cognitive decline (SCD) refers to cognitive concerns that may occur with or without objective impairment on standardized testing. Studies suggest that SCD may be an early clinical marker of Alzheimer's disease and related dementias, and that it can predict future objective …
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2026
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OpenAlex
Karen Smith, Emily E. Glavin, C. Gatsonis, Andrew March et autres
INTRODUCTION: The New Imaging Dementia-Evidence for Amyloid Scanning (IDEAS) study (NCT04426539) evaluated the association between amyloid positron emission tomography (PET) and changes in clinical management among ethnoracially diverse, clinically heterogeneous patients. METHODS: We assessed diagnosis and management plan before and 90 ± …
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2026
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OpenAlex
Charles Windon, Rachel A Whitmer, Bruce E. Hillner, Jon Steingrimsson et autres
Introduction: Relationships between Alzheimer's disease neuropathology, residential neighborhood, and cognitive impairment remain incompletely understood. Methods: We examined whether residence within a disadvantaged neighborhood was associated with amyloid positron emission tomography (PET) positivity. We used data from the observational, multisite, Imaging Dementia-Evidence for …
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2026
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OpenAlex
Lycia Tramujas Vasconcellos Neumann, Simin Mahinrad, Erin Abner, Soo Borson et autres
Abstract The field of Alzheimer's disease and related dementias (AD/ADRD) is undergoing a transformative shift with a better understanding of disease biology, biomarker‐based diagnostics, and disease‐modifying therapies. Yet, these advancements risk exacerbating existing disparities in diagnosis and care. The 2024 Alzheimer's Association …
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2026
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OpenAlex
Nikhil N. Chaudhari, Owen M. Vega, Phoebe E. Imms, Jaron M. Kawamura et autres
Abstract Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks …
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2025
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OpenAlex
Hengda He, Qolamreza Ray Razlighi, Yunglin Gazes, Christian Georg Habeck et autres
The deposition of amyloid-β (Aβ) in the human brain is a hallmark of Alzheimer’s disease and is associated with cognitive decline. Aβ pathology is traditionally assessed at the whole-brain level across neocortical regions using positron emission tomography (PET). However, these measures often …
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2025
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OpenAlex
Gloria Annette Aguirre, Magda Kaczmarska, Alexander Kornhuber, Stefanie Danielle Piña‐Escudero et autres
BACKGROUND: The rising prevalence of age-related neurocognitive disorders (NCDs) poses significant public health challenges, particularly in diverse urban populations with social and structural barriers to healthcare. Research suggests that social engagement and physical activity are key modifiable risk factors for dementia prevention. …
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2025
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OpenAlex
David N. soleimani‐Meigooni, Ganna Blazhenets, Renaud La Joie, Zoe Lin et autres
Abstract Background PET visual reads for multi‐center studies are conducted centrally by one or a few experts. In CLARiTI, a broader network of raters will perform the reads, necessitating methods to ensure their accuracy and reliability. Method All ADRC sites ( N …
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2025
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OpenAlex
Stefanie Danielle Piña‐Escudero, Jorge Archila‐Puac, Oscar Robles Archila, Gloria Annette Aguirre et autres
BACKGROUND: The Polysocial Risk Score (PSRS) is derived from the UCSF Memory and Aging Center (MAC) Social Determinants of Health (SDOH) questionnaire, which evaluates lifelong SDOH factors across various domains, including parental background, education, employment, economic stability, healthcare access, housing stability, nutrition, …
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2025
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OpenAlex
Margo B. Heston, Charles Windon, Lucy Hanna, C. Gatsonis et autres
Abstract Background Socioeconomic vulnerabilities and healthcare environment contribute to disparities in dementia assessment. Whether these affect dementia management, however, remains unclear. We used Imaging Dementia – Evidence for Amyloid Scanning (IDEAS) study data to compare the impact of amyloid PET on pharmacological …
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2025
article
OpenAlex
Charles Windon, C. Gatsonis, Justin Romanoff, Lucy Hanna et autres
BACKGROUND: Amyloid PET use has been associated with change in clinical management among cognitively impaired older adults but various ethnoracial groups were underrepresented in prior studies. New IDEAS examined whether this association exists among cognitively impaired ethnoracially diverse Medicare beneficiaries and beneficiaries …
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